Pathologic FractureBone MetastasesMetastatic Cancer
Investigational drug(s) / intervention(s)
endoprosthetic reconstructionIntramedullary nailingOpen reduction internal fixation with plate and screws
endoprosthetic reconstruction: This is a type of surgery in which the affected part of the bone and joint is removed, and replaced by a prosthesis.
Intramedullary nailing: This is a type of surgery in which the affected bone is stabilized by a nail. The affected part could be removed or retained. If removed, the defect is filled with bone cement.
Open reduction internal fixation with plate and screws: This is a type of surgery in which the affected part of the bone is visualized completely, after the reduction is achieved, the fixation is provided with appropriate plates and screws. Again the affected part could be removed or retained. If removed, the defect is filled with bone cement.
Study summary
This is a single center prospective study to compare the short term results of prosthesis, nail and plate-screw surgeries for metastatic pathologic fractures.
Eligibility
Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* metastatic pathologic fracture
* operated via endoprosthesis, intramedullary nail or plate \& screws
Exclusion Criteria:
* primary bone tumor
* conservative management
* neuromuscular disease
* periprosthetic fractures
* less than 1 month follow up
Primary outcome measure(s)
Musculoskeletal Tumor Society (MSTS) score — Preoperative MSTS score is for evaluating the patients with bone tumors. It consists of six domains; scored on a 0 to 5 scale and transformed into an overall score ranging from 0 to 100% with a higher score indicating better function.
Musculoskeletal Tumor Society (MSTS) score — Postoperative 1st day MSTS score is for evaluating the patients with bone tumors. It consists of six domains; scored on a 0 to 5 scale and transformed into an overall score ranging from 0 to 100% with a higher score indicating better function.
Musculoskeletal Tumor Society (MSTS) score — Postoperative 1st week MSTS score is for evaluating the patients with bone tumors. It consists of six domains; scored on a 0 to 5 scale and transformed into an overall score ranging from 0 to 100% with a higher score indicating better function.
Musculoskeletal Tumor Society (MSTS) score — Postoperative 1st month MSTS score is for evaluating the patients with bone tumors. It consists of six domains; scored on a 0 to 5 scale and transformed into an overall score ranging from 0 to 100% with a higher score indicating better function.
Toronto Extremity Salvage Score (TESS) — Preoperative TESS is widely used for the functional assessment of patients following surgery for musculoskeletal tumours. In the TESS system, specific movements for independent living and functionality are questioned and scored.While the worst score is 0, the best score for the lower extremity is 150, and the best score for the upper extremity is 145.
Toronto Extremity Salvage Score (TESS) — Postoperative 1st day TESS is widely used for the functional assessment of patients following surgery for musculoskeletal tumours. In the TESS system, specific movements for independent living and functionality are questioned and scored.While the worst score is 0, the best score for the lower extremity is 150, and the best score for the upper extremity is 145.
Toronto Extremity Salvage Score (TESS) — Postoperative 1st week TESS is widely used for the functional assessment of patients following surgery for musculoskeletal tumours. In the TESS system, specific movements for independent living and functionality are questioned and scored.While the worst score is 0, the best score for the lower extremity is 150, and the best score for the upper extremity is 145.
Toronto Extremity Salvage Score (TESS) — Postoperative 1st month TESS is widely used for the functional assessment of patients following surgery for musculoskeletal tumours. In the TESS system, specific movements for independent living and functionality are questioned and scored.While the worst score is 0, the best score for the lower extremity is 150, and the best score for the upper extremity is 145.
Visual analog scale (VAS) — Preoperative VAS is a widely used scale for pain. 0 means no pain where 10 means unbearable pain.
Visual analog scale (VAS) — Postoperative 1st day VAS is a widely used scale for pain. 0 means no pain where 10 means unbearable pain.
Visual analog scale (VAS) — Postoperative 1st week VAS is a widely used scale for pain. 0 means no pain where 10 means unbearable pain.
Visual analog scale (VAS) — Postoperative 1st month VAS is a widely used scale for pain. 0 means no pain where 10 means unbearable pain.
Upper Extremity Functional Scale (UEFS) — Preoperative UEFS is a functional scale for upper extremity. It is not specific for tumor patients.
Upper Extremity Functional Scale (UEFS) — Postoperative 1st day UEFS is a functional scale for upper extremity. It is not specific for tumor patients.
Upper Extremity Functional Scale (UEFS) — Postoperative 1st week UEFS is a functional scale for upper extremity. It is not specific for tumor patients.
Upper Extremity Functional Scale (UEFS) — Postoperative 1st month UEFS is a functional scale for upper extremity. It is not specific for tumor patients.
Disabilities of Arm, Shoulder and Hand (DASH) — Preoperative DASH is a widely used functional scale for upper extremity. It is not specific for tumor patients.
Disabilities of Arm, Shoulder and Hand (DASH) — Postoperative 1st day DASH is a widely used functional scale for upper extremity. It is not specific for tumor patients.
Disabilities of Arm, Shoulder and Hand (DASH) — Postoperative 1st week DASH is a widely used functional scale for upper extremity. It is not specific for tumor patients.
Disabilities of Arm, Shoulder and Hand (DASH) — Postoperative 1st month DASH is a widely used functional scale for upper extremity. It is not specific for tumor patients.
Lower Extremity Functional Scale (LEFS) — Preoperative LEFS is a functional scale for lower extremity. It is not specific for tumor patients.
Lower Extremity Functional Scale (LEFS) — Postoperative 1st day LEFS is a functional scale for lower extremity. It is not specific for tumor patients.
Lower Extremity Functional Scale (LEFS) — Postoperative 1st week LEFS is a functional scale for lower extremity. It is not specific for tumor patients.
Lower Extremity Functional Scale (LEFS) — Postoperative 1st month LEFS is a functional scale for lower extremity. It is not specific for tumor patients.
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) — Preoperative WOMAC is a widely used functional scale for lower extremity. It is not specific for tumor patients.
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) — Postoperative 1st day WOMAC is a widely used functional scale for lower extremity. It is not specific for tumor patients.
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) — Postoperative 1st week WOMAC is a widely used functional scale for lower extremity. It is not specific for tumor patients.
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) — Postoperative 1st month WOMAC is a widely used functional scale for lower extremity. It is not specific for tumor patients.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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