Resistance exercise: The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
Study summary
This study aims to investigate the effects of resistance training (RT) with different training volumes on immune modulation and anti-inflammatory responses in older adults. Participants will be randomly assigned to one of three RT volume groups (low, medium, or high) or a non-exercise control group. Participants in the training groups will complete a 4-week RT program, followed by a 4-week detraining phase. The findings are expected to provide evidence for volume-specific RT prescriptions to support healthy aging.
Eligibility
Sex
ALL
Min age
60 Years
Max age
75 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Aged 60-75 years or older
* No regular resistance training habit (defined as ≥2 sessions per week) in the past year
* No musculoskeletal injuries within the past six months
Exclusion Criteria:
* Obesity (BMI \> 30 kg/m²), diabetes, hypertension, cancer, heart, kidney, or liver disease, or any other condition that may influence study outcomes.
* Regular use of anti-inflammatory medications (e.g., NSAIDs).
* Smoking or alcohol abuse
* Inability to safely perform the prescribed resistance exercise movements
* Unable to fully comprehend the study information and instructions.
Primary outcome measure(s)
Changes in IL-6 concentration — Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining Plasma IL-6 concentrations will be measured and reported in pg/mL.
Changes in soluble IL-6 receptor concentration — Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining Soluble IL-6 receptor concentrations will be measured and reported in ng/mL.
Changes in soluble gp130 concentration — Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining Soluble gp130 concentrations will be measured and reported in ng/mL.
Changes in IL-10 concentration — Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining IL-10 concentrations will be measured and reported in pg/mL.
Changes in IL-1RA concentration — Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining IL-1RA concentrations will be measured and reported in pg/mL.
Changes in TNF-α concentration — Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining TNF-α concentrations will be measured and reported in pg/mL.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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