The Prevalence, Risk Factors and Optimal Biopsy Protocol of BE

Condition(s) studied

Investigational drug(s) / intervention(s)

One biopsy: To do one biopsy at the proximal part of the longest columnar-lined esophagus.

Three biopsy: To do three biopsy at the proximal, middle and distal part of the longest columnar-lined esophagus.

Seattle protocol: To do 4-quadrant biopsy every 1-2 cm at the esophagogastric junction. Seattle protocol has been considered as the gold standard biopsy protocol for patients with suspected Barrett's Esophagus.

Endoscopy: The participants will receive meticulous endoscopic examination with narrow-band imaging.

Study summary

Detections of goblet cells and dysplasia are crucial for diagnosis and determining the surveillance program of Barrett's esophagus (BE). However, the optimal biopsy numbers and their yield rates of intestinal metaplasia (IM) and dysplasia are still uncertain, especially in Asia. The aim of this study was to determine the optimal biopsy protocol of BE.

Eligibility

Primary outcome measure(s)

• The yield rate of intestinal metaplasia — Up to 7 days histologic confirmation
  Defined as the proportion of histologic confirmation of goblet cells

Trial sites (1)

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