Atherosclerotic Plaque Imaging Project (CPIP)

Condition(s) studied

Investigational drug(s) / intervention(s)

Study summary

The rupture or erosion of an atherosclerotic plaque with thrombosis or embolization often underlie heart attacks and strokes. The early identification of patients with atherosclerotic plaques prone to rupture or erosions, vulnerable plaques (VP), and their treatment before the occurrence of events is, therefore, one of the greatest cardiovascular challenges today. Possible approaches for early detection of VP include imaging techniques allowing visualization of plaque structure, circulating biomarkers and better understanding of the pathophysiologic mechanisms of the disease. In the carotid plaque imaging project the investigators study human atherosclerotic plaques (that are removed by endarterectomy) to disclose their underlying structure and mechanisms, finding possible novel therapeutic targets or markers for VP. The investigators also study plaque structure with imaging methods and try to develop new ways to detect VP using circulating or imaging markers.

Eligibility

Primary outcome measure(s)

• Number of participants suffering post-operative cardiovascular events (by 2025) — Follow up assessment year 2025 (recording of events occurring since 2023)
  Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)
• Number of participants suffering post-operative cardiovascular events (by 2027) — Follow up assessment year 2027 (recording of events occurring since 2025)
  Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)
• Number of participants suffering post-operative cardiovascular events (by 2029) — Follow up assessment year 2029 (recording of events occurring since 2027)
  Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)

Trial sites (1)

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