High intensity interval training (HIIT): HIIT performed either in the morning or in the afternoon
Study summary
Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian rhythm in mediating response to exercise in a variety of insulin sensitive organs.
The aim of this project is to evaluate, by intervention, the interplay of circadian rhythm and high intensity interval training (HIIT) on glucose control and skeletal muscle metabolism in patients with overweight with or without type 1 diabetes (T1D).
Eligibility
Sex
ALL
Min age
18 Years
Max age
50 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* BMI 25-30
* type 1 diabetes or healthy subjects
Exclusion Criteria:
* nicotine usage,
* cardiovascular disease (CVD),
* blood pressure \>160/95,
* pregnancy,
* treatment with other pharmaceutical drugs than insulin, stable dose of thyroid hormone, statins, and antihypertensive drugs (excluding beta blockers).
Additional exclusion criteria for diabetes subjects:
* diabetes duration less than 6 months,
* proliferative or severe non-proliferative retinopathy,
* chronic kidney disease with glomerular filtration rate (GFR) \<60 ml/min,
Primary outcome measure(s)
Time in Glucose target range (4-10 mmol/L) for tissue glucose from CGM. — 48 hours Time in target glucose range (expressed as % of total time) measured by continuous subcutaneous glucose sensors following morning or afternoon HIIT respectively. Measurements are uploaded from the CGM device and analyzed.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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