BIOANCIENT: Cohort of Centenarians in Navarra (1926-1927)

NCT07707297 · tracked via the Priya Life Science Spain tracker

Sponsor

Fundacion Miguel Servet

Phase

Observational

Started

2026-02-04

Last updated

2026-07-16

Condition(s) studied

AgingCellular SenescenceBiomarkers / BloodAge-Related DiseasesFrailty

Study summary

Demographic aging is a growing global challenge, driven by increasing life expectancy and declining birth rates, with projections indicating that more than 30% of the European population will be over 65 years old by 2100. Centenarians represent a unique biological model of extreme longevity, often exhibiting delayed onset of age-related diseases and preserved functional capacity.

This study aims to establish an intergenerational cohort of centenarians in Navarra (Spain) to investigate the biological, clinical, environmental, and lifestyle factors associated with extreme longevity. By integrating multidimensional data-including clinical assessments, functional and cognitive measures, and biological markers-this study seeks to improve understanding of aging mechanisms and identify potential determinants of healthy aging.

Eligibility

Sex

ALL

Min age

100 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Individuals aged ≥100 years * Residents of Navarre, Spain Exclusion Criteria: * Clinical decompensation within the last month, including hemodynamic instability, acute illness, or hospitalization; * End-of-life condition, defined as a clinical state of irreversible deterioration with a life expectancy of days to weeks, as determined by a physician.

Primary outcome measure(s)

Integrated biological aging profile based on clinical and multi-omics biomarkers. — Baseline and 1-year follow-up
Clinical, funtional and molecular characterization of centenarian individuals using multi-omics biomarkers

Trial sites (1)

Facility	City	Region	Status
Navarrabiomed	Pamplona	Navarre	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07707297 on ClinicalTrials.gov ↗ ← All trials in Spain