Control group (receiving standard medical therapy alone)Hatha yoga
Control group (receiving standard medical therapy alone): * Continuation of usual pharmacological migraine treatment
* No structured exercise/yoga program
* Usual clinical follow-up
* Post-study access to yoga program offered
Hatha yoga: * Online Hatha Yoga Program (12 weeks + 2-week follow-up)
* 2 sessions per week
* 30-45 minutes per session
* Asynchronous video-based home practice
* Standard pharmacological treatment maintained
Study summary
This randomized controlled trial aims to evaluate the effectiveness and feasibility of an online Hatha yoga program as an adjunct (add-on) therapy for patients with high-frequency episodic migraine. Participants will be randomly assigned to either an intervention group receiving a 12-week home-based online Hatha yoga program in addition to usual pharmacological treatment, or a control group receiving usual pharmacological care only. Outcomes include migraine frequency, pain intensity, functional disability, sleep quality, psychological symptoms, and adherence.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria
* Adults aged 18-65 years
* Diagnosis of episodic high-frequency migraine according to ICHD criteria
* Diagnosis confirmed by a neurologist
* At least 1-year history of migraine
* Receiving stable pharmacological treatment for ≥3 months before enrollment
* Willing to maintain stable medication during the study
* Ability to understand study procedures and complete assessments
* Signed informed consent
* Willingness to be randomized
Exclusion Criteria
* Other significant neurological disorders
* Severe psychiatric conditions affecting participation
* Medical contraindications to moderate physical activity
* Chronic migraine (≥15 headache days/month)
* Use of more than one preventive migraine medication
* Lack of Spanish language comprehension
* Lack of internet access or digital skills for online intervention
Primary outcome measure(s)
Migraine Frequency — Baseline and Week 14 Number of migraine days per month recorded via headache diary
Migraine Pain Intensity — Baseline and Week 14 Visual Analogue Scale (VAS/EVA 0-10), daily recorded and averaged
Functional Impact of Migraine — Baseline and Week 14 HIT-6 and MIDAS questionnaire scores
Percentage of Completed Yoga Sessions — Weeks 1 through 12 Adherence to the yoga program assessed as the percentage of prescribed Hatha Yoga sessions completed during the 12-week intervention period. Values range from 0% to 100%, with higher percentages indicating greater adherence to the intervention.
Exercise Adherence Rating Scale Score — Week 14 General adherence to the yoga program assessed using the Exercise Adherence Rating Scale (EARS). The EARS includes 6 items scored on a 0-4 Likert scale, with total scores ranging from 0 to 24. Higher scores indicate greater exercise adherence.
PADEX Checklist Score — Week 14 Program-related adherence facilitators assessed using the Promoting Adherence to Physical Exercise (PADEX) checklist. The PADEX checklist includes 23 dichotomous Yes/No items. The score will be expressed as the percentage of affirmative responses, ranging from 0% to 100%. Higher percentages indicate a greater presence of program features supporting adherence.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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