Wrist InjuryHand and Upper Limb TraumaMuskuloskeletal Diseases
Investigational drug(s) / intervention(s)
Orthopedic ImmobilizationStandard Rehabilitation
Orthopedic Immobilization: Standard orthopedic immobilization of the upper limb (wrist/hand) as part of routine clinical management following fracture or soft tissue injury.
Standard Rehabilitation: Conventional wrist and hand rehabilitation provided according to clinical practice after immobilization removal.
Study summary
This study aims to investigate how temporary immobilization of the upper limb after injury affects brain activity and functional recovery.
Participants with fractures or soft tissue injuries of the upper limb who require immobilization will be evaluated at three time points: at the beginning of immobilization, after removal of the immobilization, and four weeks later.
Brain activity will be measured using electroencephalography (EEG), a non-invasive and painless technique that records electrical signals from the scalp. Functional outcomes such as pain, mobility, strength, and daily activity performance will also be assessed using validated questionnaires and clinical tests.
The purpose of this study is to better understand how immobilization influences the brain and physical recovery, in order to improve rehabilitation strategies for patients with upper limb injuries.
Participation is voluntary, and all participants will provide written informed consent.
Eligibility
Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria:
* Adults aged 18 years or older.
* Radiologically confirmed upper limb fracture (distal radius, proximal humerus, metacarpals, phalanges, or carpal bones) or soft tissue injury (e.g., tendinopathy, triangular fibrocartilage complex injury).
* Requirement of orthopedic immobilization of the wrist/hand extending to the proximal two-thirds of the forearm for a minimum of 2 weeks and a maximum of 8 weeks.
* Ability to understand study procedures and follow instructions.
* Provision of written informed consent.
Exclusion Criteria:
* History of neurological disorders (e.g., stroke, epilepsy, traumatic brain injury).
* Current use of psychoactive or anticonvulsant medication.
* Bilateral upper limb injuries.
* Wrist fractures requiring elbow immobilization.
* Previous upper limb fracture or instability within the last 2 years.
* Cognitive impairment preventing adequate participation.
Primary outcome measure(s)
Change in Sensorimotor Cortical Activity Measured by EEG — Baseline (within 5 days of immobilization), 24-48 hours after immobilization removal, and 4 weeks post-removal. Changes in sensorimotor cortical activity measured using electroencephalography (EEG), including spectral power in mu (8-13 Hz) and beta (13-30 Hz) frequency bands over central regions (C3, C4 and adjacent electrodes), and functional connectivity between motor and somatosensory areas.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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