This prospective observational cohort study evaluates a community-based supervised exercise oncology program delivered in real-world settings in Madrid, Spain. The program is designed for adults with a cancer diagnosis across the cancer continuum, including survivors, patients undergoing active treatment, individuals receiving hormonotherapy, and patients with metastatic disease.
Participants take part in a structured multimodal exercise program combining aerobic, resistance, and functional training, delivered in supervised group-based sessions either in person or through synchronous online formats. The primary aims of the study are to assess program adherence, health-related quality of life, fatigue, and cost-effectiveness, expressed as quality-adjusted life years (QALYs). Secondary outcomes include cardiorespiratory fitness, muscular strength, functional capacity, physical activity levels, body composition, and psychological well-being.
Assessments are conducted at baseline and every four months over a 12-month follow-up period. This study provides real-world evidence on the feasibility, clinical impact, and economic value of community-based exercise oncology programs across different stages of the cancer trajectory.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age ≥18 years.
* Confirmed diagnosis of cancer, at any stage of disease.
* Medical clearance to perform moderate-intensity physical exercise.
* Able to ambulate independently without assistive devices.
* Willingness to attend supervised exercise sessions for a follow-up period of at least 12 months.
Exclusion Criteria:
* Absolute medical contraindications to exercise (e.g., unstable angina, uncontrolled arrhythmias, severe anemia, acute infection, or thrombosis).
* Unstable metastatic bone disease without radiologic and/or oncologic clearance.
* Cognitive or functional impairment preventing safe participation in the exercise program.
* Concurrent participation in another structured exercise intervention or clinical trial.
Primary outcome measure(s)
Adherence — Baseline, 4 months, 8 months, and 12 months. Percentage of supervised exercise sessions completed out of scheduled sessions.
Health-related quality of life (FACT-G) — Baseline, 4 months, 8 months, and 12 months. Health-related quality of life (units on a scale) assessed using the Functional Assessment of Cancer Therapy - General (FACT-G)
Fatigue (FACT-F) — Baseline, 4 months, 8 months, and 12 months. Fatigue (units on a scale) assessed using the Functional Assessment of Chronic Illness Therapy - Fatigue (FACT-F).
Quality-adjusted life years (QALYs) — Baseline, 4 months, 8 months, and 12 months. Quality-adjusted life years calculated by integrating EQ-5D utility scores collected at multiple time points over the 12-month follow-up period. Repeated EQ-5D measurements are aggregated to derive a single QALY value per participant.
Barriers to participation — Baseline, 4 months, 8 months, and 12 months. Using a structured questionnaire based on previously published frameworks on determinants of adherence in cancer survivors.
Trial sites (1)
Facility
City
Region
Status
Ejercicio y Cáncer Center
Madrid
Madrid
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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