Diet supplementation: The severities of chronic disease symptoms correlate with the levels of analytical parameters of inflammation. Studies have been published in which the Mediterranean diet has an anti-inflammatory phenomenon, decreasing inflammation parameters. This decrease correlates with an improvement in symptoms .
Endometriosis is a chronic inflammatory disease and the influence of the Mediterranean diet on the decrease of inflammation parameters in women with endometriosis has been studied.
Study summary
The severities of chronic disease symptoms correlate with the levels of analytical parameters of inflammation. Studies have been published in which the Mediterranean diet has an anti-inflammatory phenomenon, decreasing inflammation parameters. This decrease correlates with an improvement in symptoms.
Endometriosis is a chronic inflammatory disease and the influence of the Mediterranean diet on the decrease of inflammation parameters in women with endometriosis has been studied.
The studies carried out to assess whether this decrease in inflammatory parameters correlates with clinical improvement and quality of life in these patients have low/very low scientific evidence (small sample size, no control group) and with different interventions (diets, restrictions and/or supplements), which prevent their analysis as a whole.
Therefore, our hypothesis is that the Mediterranean diet, due to its anti-inflammatory effect, can improve the symptomatology and quality of life of patients with endometriosis.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
45 Years
Healthy volunteers
No
INCLUSION CRITERIA:
* Female.
* Age 18-45.
* Premenopausal status.
* Radiological diagnosis (by transvaginal ultrasound and/or MRI) and/or surgical diagnosis of endometriosis.
* Follow-up in the Gynecology Department of OSI Donostia (at least 1 visit in the last year).
* Clinical score of at least 3/10 on the Numerical Scale in at least one symptom related to endometriosis).
* Possibility of understanding Spanish.
* Possibility of understanding the indicated dietary recommendations.
* Acceptance of inclusion in clinical study, by signing informed consent.
EXCLUSION CRITERIA:
* Diagnosis of Eating Disorder.
* Diagnosis of malabsorptive syndromes: Chron's disease, Ulcerative colitis, short bowel syndrome, gastric by-pass, irritable bowel.
* Other concomitant diseases that produce CPD.
* Autoimmune diseases.-
* Metabolic diseases requiring follow-up of specific diets.
* Diagnosed gluten intolerance.
* Vegan diet.
* Follow-up by a nutritionist.
* Diagnosis of severe mental illness requiring treatment.
* Pregnancy or current breastfeeding.
* Active cancer process.
* Personal history of gynecologic or digestive oncologic process.
* Change of treatment or surgery during follow-up.
* Surgery related to endometriosis or change of treatment in the 6 weeks prior to enrollment in the study.
* Drug abuse. Opioid analgesia \< 3 months.
Primary outcome measure(s)
Quality of life and endometriosis. — 24 weeks Endometriosis Health Profile 30 (EHP-30) questionnaire (0-100)
Pain intensity in symptoms related to endometriosis — 24 weeks Pain with menstruation or Dysmenorrhea - A numeric scale (0-10)
Pain intensity in symptoms related to endometriosis — 24 weeks Pain with sexual intercourse or Dyspareunia - A numeric scale (0-10)
Pain intensity in symptoms related to endometriosis — 24 weeks Pain with defecation or Dyschezia - A numeric scale (0-10)
Pain intensity in symptoms related to endometriosis — 24 weeks Pain with urination or Dysuria - A numeric scale (0-10)
Pain intensity in symptoms related to endometriosis — 24 weeks Non-menstrual pelvic pain - A numeric scale (0-10)
Pain intensity in symptoms related to endometriosis — 24 weeks Abdominal bloating or distension - A numeric scale (0-10)
Pain intensity in symptoms related to endometriosis — 24 weeks Tiredness - A numeric scale (0-10)
Trial sites (1)
Facility
City
Region
Status
Hospital Universitario Donostia (HUD)
Donostia / San Sebastian
Gipuzkoa
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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