Intraligamentary Injection: Intraligamentary local anesthesia will be administered using a standard dental syringe with 2% lidocaine and 1:100,000 epinephrine.
Inferior Alveolar Nerve Block: Inferior alveolar nerve block will be performed with 2% lidocaine and 1:100,000 epinephrine using the conventional technique.
Study summary
This multicenter randomized trial compares the clinical effectiveness of intraligamentary injection versus inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis in mandibular molars. The goal is to determine which technique provides better pain control during endodontic treatment.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* Adults aged 18 years or older
* Presenting with symptomatic irreversible pulpitis in a mandibular molar
* Vital response to cold testing
* Ability to understand and provide informed consent
* Available for follow-up and data collection
Exclusion Criteria:
* Known allergy to lidocaine or epinephrine
* Pregnancy or breastfeeding
* Use of analgesics or anti-inflammatory drugs in the previous 6 hours
* Non-vital or previously treated teeth
* Significant systemic disease (ASA III or above)
* History of psychiatric or neurological disorders affecting pain perception
Primary outcome measure(s)
Pain during endodontic access — Immediately after access cavity preparation (within 30 minutes of anesthesia) Pain intensity experienced by the patient during endodontic access after the assigned anesthetic technique.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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