Triggering Ovulation at Follicle Size Smaller or Larger Than 17mm in a Modified Natural Cycle

Condition(s) studied

Investigational drug(s) / intervention(s)

Trigger at smaller folicular size: Trigger indicated at folicular diameter smaller than standard clinical practice, from 13mm to 16.9mm

Study summary

The rise in frozen embryo transfer (FET) cycles within assisted reproductive technology (ART) has sparked the need to refine endometrial preparation protocols. The switch from hormone replacement cycles (HRT) to natural cycles, poses scheduling challenges onto laboratories, doctors and patients. The modified natural cycle (mNC), offering more precision for scheduling, shows promise but lacks comprehensive data on the potential flexibility of triggering criteria that may allow to control timing in a wider range.

This prospective randomized study seeks to address this knowledge gap by evaluating the non-inferiority of triggering ovulation in mNC with follicle diameters of 13-16.9mm compared to the conventional 17-22mm.

The study aims to enhance the understanding of the impact of follicle size at ovulation in reproductive outcomes, optimize FET treatments providing a more flexible mNC protocol, and improve patient care in ART clinics.

Eligibility

Primary outcome measure(s)

• Pregnancy rate — From embryo transfer up to 2 weeks later
  Rate of positive pregnancies over total transfers performed, according to beta-test result

Trial sites (1)

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