Cognitive behavioral therapy (CBT) + Functional Remediation (FR): VECTOR will provide a newly designed intervention, based on the adaptation of two existing evidence-based and effective interventions (CBT for ADHD and FR for BD)(Corrales et al., 2024; Torrent et al., 2013).
Study summary
Cognitive dysfunctions are present in Bipolar Disorder (BD) and Attention Deficit Hyperactivity Disorder (ADHD) and may negatively impact psychosocial functioning. Further, comorbid BD and ADHD (BD-ADHD) is prevalent, associated with an earlier BD onset and a less favorable prognosis. Nevertheless, there is a paucity of research dedicated to the characterization and treatment of comorbid BD-ADHD.
This study aims to develop and evaluate the effectiveness of a novel psychological group intervention (VECTOR) for adults with BD-ADHD. VECTOR integrates elements from Cognitive Behavioral Therapy (CBT) for ADHD and Functional Remediation (FR) for BD.
Eighty patients will be randomized (1:1) to receive either the VECTOR program (12 weekly group sessions) or treatment as usual (TAU).
It is expected that the VECTOR program will result in greater improvements in functioning and symptom reduction compared to TAU.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Fulfill DSM-5 criteria for BDI or BDII and ADHD using the Structured Clinical Interview for DSM-5 and the Conners' Adult ADHD Diagnostic Interview (CAARS)
* Aged ≥18
* Stable pharmacological treatment for at least the past three months.
* Being in full or partial remission Young Mania Rating Scale (YMRS) ≤ 10, Hamilton Depression Rating Scale (HDRS) ≤ 14) at the time of the inclusion and assessment
* ADHD rating scale≥24
Exclusion Criteria:
* Any comorbid psychiatric condition
* Diagnosis of substance abuse disorder in the past 12 months
* Intellectual disability (intelligence quotient \< 70)
* Having any Central Nervous System illness, independent of primary psychiatric diagnosis, hampering neuropsychological performance
* Participation in a structured psychological intervention during the study period.
Primary outcome measure(s)
Functioning Assessment Short Test (FAST) — Baseline, post-treatment (12 weeks) and 12 months 24-item scale assessing disability in six functional domains: autonomy, occupational functioning, cognitive functioning, financial issues, interpersonal relationships, and leisure time. Assessed by a blind expert rater.
Clinical Global Impression - Severity (CGI-S) — Baseline, post-treatment (12 weeks) and 12 months Severity scale measuring global symptom severity. Assessed by a blind expert rater.
Trial sites (1)
Facility
City
Region
Status
Hospital Clínic de Barcelona and Vall d'Hebron University Hospital
Barcelona
Barcelona
More Hospital Universitari Vall d'Hebron Research Institute trials in Spain
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.