PREVAIL Paclitaxel-coated Balloon in Small Coronary Disease and High-bleeding Risk Patients

Inclusion Criteria: Patients with: * PCI with DCB on native arteries with diameters \< 3 mm. * Indication for PCI in acute coronary syndrome or chronic coronary syndrome or silent angina with an indication for PCI. syndrome or silent angina with an indication for PCI. * If previous lesion preparation was required after which angiographic residual lesion should not exist with diameter stenosis \> 30% or flow-limiting coronary dissections. * All antithrombotic therapies administered prior to the procedure are accepted. Still, they can be changed after the procedure. * Capacity to understand and sign the written informed consent. * If the patient has a high-bleeding risk defined by 1) PRECISE-DAPT SCORE ≥ 25 or 2) an indication for concomitant oral anticoagulation he can be included in the high- bleeding risk substudy as long as he does not meet the specific exclusion criteria. Exclusion Criteria: Patients with: * Concomitant lesions on vessels \> 3 mm in diameter in the same coronary territory. * PCI on in-stent restenoses. * PCI on culprit lesions of acute coronary syndrome with ST segment elevation. * Patients with an indication for PCI on additional non-culprit lesions of acute coronary syndrome with ST segment elevation may be included in the study, if only non-culprit lesions are considered for the study. * Life expectancy \<12 months * Pregnancy. * Participation in clinicaltrials. * Inability to give the written informed consent. * Specific exclusion criteria for the high-bleeding risk patient subgroup: * Past medical history of stent thrombosis. * Indication for dual antiplatelet therapy for a different reason.