Extracorporeal support with haemoperfusionConventional treatment
Extracorporeal support with haemoperfusion: Use of extracorporeal support with haemoperfusion
Conventional treatment: Conventional treatment
Study summary
Low-level interventional clinical trial to evaluate the effectiveness and safety of extracorporeal support with hemoperfusion in critical patients with septic multiorgan dysfunction syndrome.
Eligibility
Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients with a sepsis diagnosis, according to the diagnostic criteria of the International Sepsis-3 Consensus Conference, and without response to the treatment of septic shock who meet the following conditions:
* Sepsis of abdominal origin with controlled infectious focus.
* Noradrenaline dose\> 0.5 µg / kg / min to maintain adequate organ perfusion after optimization of fluid therapy.
* Dysfunction of two or more organs with SOFA ≥ 9 (5).
* Blood lactate ≥ 2 mmol / L.
* Procalcitonin (PCT)\> 10 ng / mL.
* CRP\> 100 mg / L.
* IL-6\> 2000 pg / ml.
Exclusion Criteria:
* Age under 18 years or over 80 years.
* Pregnancy or breastfeeding.
* Terminally ill patients or with a life expectancy of less than 48 hours.
* Thrombocytopenia \<60,000 / mm3.
* Pancytopenia.
* Severe coagulopathy with high risk of bleeding.
* Inclusion in another research protocol.
* In case of re-entry during the study period, only the first admission will be included.
* Use of another haemoperfusion device.
Primary outcome measure(s)
IL-6 plasmatic concentration — During hemoperfusion Analyze the patient's variation of IL-6 plasmatic concentration during the hemoperfusion process
Adverse events — During hemoperfusion Analyze the presence of adverse events during the hemoperfusion process
Organ failure — During hemoperfusion Analyze the number and severity of failed organs during the hemoperfusion process
Vasopressors dose — During hemoperfusion Analyze the patient's vasopressor dose variation during the hemoperfusion process
Mean arterial pressure — During hemoperfusion Analyze the patient's variation of mean arterial pressure during hemoperfusion
Vasopressors dose — During ICU stay Analyze the number of days on vasopressor support during ICU stay
Mechanical ventilation — During ICU stay Analyze the number of days on mechanical ventilation during ICU stay
Renal replacement therapy — During ICU stay Analyze the number of days on renal replacement therapy during ICU stay
ICU length of stay — Post-Intensive Care Unit discharge Analyze the patient's length of stay in ICU
ICU survival — Post-Intensive Care Unit discharge Analyze the patient's survival in ICU
Hospital stay — post-hospital discharge Analyze the patient's length of stay post-Intensive Care Unit discharge
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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