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Clinical Trials in Spain / NCT00005584
Active, not recruiting Phase 3

Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma

NCT00005584 · tracked via the Priya Life Science Spain tracker
Phase
Phase 3
Started
1998-10
Last updated
2025-08-05

Condition(s) studied

Lymphoma

Investigational drug(s) / intervention(s)

bleomycin sulfate →ABVD regimen →BEACOPP regimenepirubicin hydrochloride →prednisone →vinblastine sulfate →radiation therapy

Study summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy with radiation therapy may kill more cancer cells. It is not yet known which combination chemotherapy regimen is most effective in treating Hodgkin's lymphoma.

PURPOSE: Randomized phase III trial to compare the effectiveness of different regimens of combination chemotherapy with or without radiation therapy in treating patients who have Hodgkin's lymphoma.

Eligibility

Sex
ALL
Min age
15 Years
Max age
70 Years
Healthy volunteers
No
DISEASE CHARACTERISTICS: * Randomized groups: Histologically proven previously untreated stage I or II supradiaphragmatic Hodgkin's lymphoma * No prior staging laparotomy * Favorable (closed to accrual as of 4/28/04) or unfavorable (closed to accrual as of 9/2002) prognosis * Nonrandomized group: Histologically proven lymphocyte-predominant Hodgkin's lymphoma, nodular subtype (nodular paragranuloma) * Stage I with complete or incomplete resection OR * Stage II PATIENT CHARACTERISTICS: Age: * 15 to 70 Performance status: * WHO 0-2 Life expectancy: * Not specified Hematopoietic: * Not specified Hepatic: * Not specified Renal: * Not specified Cardiovascular: * No severe cardiac disease that would interfere with normal life expectancy or study treatment Pulmonary: * No severe pulmonary disease that would interfere with normal life expectancy or study treatment Other: * No other prior or concurrent malignancy except basal cell skin cancer or carcinoma in situ of the cervix * No severe neurologic or metabolic disease that would interfere with normal life expectancy or study treatment * No psychologic, familial, socioeconomic, or geographic circumstances that would preclude proper staging or compliance * HIV negative * Not pregnant * Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy * No prior biologic therapy for this malignancy Chemotherapy * No prior chemotherapy for this malignancy Endocrine therapy * No prior endocrine therapy for this malignancy Radiotherapy * No prior radiotherapy for this malignancy Surgery * No prior surgery for this malignancy

Primary outcome measure(s)

Trial sites (121)

FacilityCityRegionStatus
Sint Augustinus Ziekenhuis Antwerp Belgium
A.Z. St. Jan Bruges Belgium
C.H.U. Saint-Pierre Brussels Belgium
Institut Jules Bordet Brussels Belgium
Cliniques Universitaires Saint-Luc Brussels Belgium
Centre Hospitalier Universitaire Brugmann Brussels Belgium
Universitair Ziekenhuis Antwerpen Edegem Belgium
U.Z. Gasthuisberg Leuven Belgium
Clinique Universitaire De Mont-Godinne Mont-Godinne Yvoir Belgium
Clinique Saint-Pierre Ottignies Belgium
Centre Hospitalier Annemasse Bonneville Ambilly France
Centre Hospitalier d'Annecy Annecy France
Centre Hospital General Robert Ballanger Aulnay-sous-Bois France
Hopital Duffaut Avignon France
Centre Hospitalier de la Cote Basque Bayonne France
CHR de Besancon - Hopital Jean Minjoz Besançon France
Hopital de Beziers Béziers France
Hopital Saint Andre Bordeaux France
Institut Bergonie Bordeaux France
C.H. Bourg En Bresse Bourg-en-Bresse France
CMC Bligny Briis-sous-Forges France
CHU de Caen Caen France
Centre Regional Francois Baclesse Caen France
Centre Hospitalier Regional de Chambery Chambéry France
Hopital Fontenoy Chartres France
Centre d'Oncologie et de Radiotherapie de Chaumont le Bois Chaumont France
Hopital d'Instruction des Armees Percy Clamart France
Hopital Antoine Beclere Clamart France
Hopital Beaujon Clichy France
Hopital Louis Pasteur Colmar France
Centre Hospitalier Compiegne Compiègne France
Centre Hospitalier Sud Francilien - Site Corbeil Corbeil France
Centre Hospitalier Universitaire Henri Mondor Créteil France
Hopital Du Bocage Dijon France
Centre de Lutte Contre le Cancer, Georges-Francois Leclerc Dijon France
Institut Prive de Cancerologie Grenoble France
Centre Hospitalier Juvisy-sur-Orge France
Hopital Andre Mignot Le Chesnay France
C.H.G. Du Havre - Hopital J. Monod Le Havre France
Centre Hospitalier Universitaire de Bicetre Le Kremlin-Bicêtre France

+ 81 more sites — see the full list on the official registry below.

On this site

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More European Organisation for Research and Treatment of Cancer - EORTC trials in Spain

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT00005584 on ClinicalTrials.gov ↗ ← All trials in Spain