This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). While some studies suggest that oXiris® may improve hemodynamic stability by removing endotoxins and cytokines, its impact on survival remains inconsistent.To provide more reliable causal evidence, this multicenter retrospective cohort study utilizes a Target Trial Emulation (TTE) approach. The study will compare patients treated with the oXiris® filter to those treated with standard CRRT filters, focusing on in-hospital mortality and other clinical outcomes such as fluid balance and vasopressor requirements.
Eligibility
Sex
ALL
Min age
19 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adults aged 19 years or older.
* Admitted to the ICU with septic shock (Sepsis-3 criteria) between March 2021 and August 2025.
* Required Continuous Renal Replacement Therapy (CRRT) due to acute kidney injury (AKI).
Exclusion Criteria:
* Death or withdrawal of life-sustaining therapy within 48 hours of ICU admission.
* Patients with End-Stage Renal Disease (ESRD).
* Patients with missing critical covariates.
Primary outcome measure(s)
In-hospital Mortality — From the initiation of CRRT (Time zero) until hospital discharge or death. The primary objective is to evaluate the causal effect of oXiris® hemofilter use on survival during the hospital stay compared to standard CRRT. Statistical analysis will be performed using an Inverse Probability of Treatment Weighting (IPTW)-weighted Cox proportional hazards model to adjust for baseline and time-varying confounders.
Trial sites (1)
Facility
City
Region
Status
Seoul National University Bundang Hospital
Seongnam-si
Gyeonggi-do
Recruiting
More Seoul National University Bundang Hospital trials in South Korea
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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