Anorexia of AgingMalnutrition or Risk of Malnutrition
Investigational drug(s) / intervention(s)
Shredded Chicken Congee
Shredded Chicken Congee: This is a mixed meal tolerance test intended to elicit gut hormone responses reflective of real-world dietary patterns.
Study summary
The study aims to identify key physiological factors that differentiate older adults with healthy appetites from those experiencing appetite decline. The investigators hypothesize that seniors experiencing appetite decline will exhibit distinct oro-sensory, gastrointestinal, and hormonal profiles compared to seniors with healthy appetites, suggesting underlying biological mechanisms contributing to reduced appetite.
Eligibility
Sex
FEMALE
Min age
65 Years
Max age
74 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Postmenopausal female
* Aged 65-74 years
* Habitual breakfast consumer (consumes breakfast between 7am to 10am)
* Willingness to consume meals and follow intervention protocol
* English speaking
Exclusion Criteria:
* BMI ≥ 27.5
* Diagnosed with medical condition that may influence appetite or microbiome (e.g. diabetes, thyroid disorders, gastrointestinal diseases)
* Currently taking any medications or supplements that may influence appetite or the microbiome (e.g. probiotics, antibiotics, appetite stimulants/suppressants) one month prior to their first visit in consultation with study physician, PI and study team
* Following a special diet for weight management (e.g. low-calorie, low carbohydrate)
* History of bariatrics surgery
* Intentional attempt to change body weight or composition
* History of severe vasovagal syncope (blackouts or near faints) following blood draw
* Drug abuse within last 5 years
* Excessive alcoholic beverage consumption \> 2 servings per day (1 serving defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits)
* Smoking (cigarette, e-cigarette, cigar, pipe, vape)
* Engaging in habitual vigorous physical activity (as defined by physical activity questionnaire-PAQ)
* Loose teeth or jaw pain
* Not missing \> 2 non-wisdom molars
* Involvement in other clinical studies that may influence the outcome of the study
* A study team member or their immediate family member
Primary outcome measure(s)
Ad Libitum Lunch — Participants will be given 30 minutes to consume the meal until they are comfortably full, 180 minutes after the start of the intervention. Participants will be asked to eat as much of the stir-fried beehoon as they want until they are comfortably full, to measure the exact calorie intake by weighing the food before and after eating.
Trial sites (1)
Facility
City
Region
Status
Clinical Nutrition Research Centre
Singapore
Singapore
More Singapore Institute of Food and Biotechnology Innovation trials in Singapore
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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