GVHD, ChronicGVHD - Graft-Versus-Host DiseaseGVHDQuality of LifeDepression DisordersCognitive Impairments
Study summary
This prospective observational study evaluates the association between psychiatric status, GvHD-related symptom severity, and health-related quality of life in patients with graft-versus-host disease. Standardized and validated assessment tools, including the Lee Symptom Scale, will be used to collect psychiatric, clinical, and demographic data.
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* Adult patients with a clinically established diagnosis of graft-versus-host disease (GvHD) receiving specialist follow-up care at the Bone Marrow Transplantation Outpatient Clinic, University Clinical Center (UCK), Gdańsk.
Exclusion Criteria:
* Severe psychiatric disorders precluding adequate cooperation, terminal-stage multiorgan failure, or refusal to provide informed consent for study participation.
Primary outcome measure(s)
Identification of depression as a factor associated with increased GvHD-related symptom burden and reduced health-related quality of life. — Baseline and follow-up assessments during the study period (up to 12 months).
Assessment of therapeutic benefits associated with combined antidepressant treatment and psychotherapy, antidepressant treatment alone, and psychotherapy alone. — Baseline and follow-up assessments during the study period (up to 12 months).
Support for the integration of systematic psychiatric assessment into standard multidisciplinary care protocols for patients with graft-versus-host disease. — Baseline and follow-up assessments during the study period (up to 12 months).
Trial sites (1)
Facility
City
Region
Status
Department of Hematology and Transplantology
Gdansk
Pomeranian Voivodeship
Recruiting
More Medical University of Gdansk trials in Poland
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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