Supplementation With Sirtuin Activators in Women With Increased Body Weight

Condition(s) studied

Investigational drug(s) / intervention(s)

Sirtuin activators: Sirtuin acitivators supplementation for 6 months

Placebo: Placebo supplementation for 6 months

Study summary

The goal of this clinical trial is to learn if the six-month supplementation with sirtuin activators can affect metabolism in 40-to-65-year old women with increased body weight. The main questions it aims to answer are:

Does sirtuin activators affect lipid and carbohydrate metabolism? Does sirtuin activators affect oxydative stress, immune functions and cell ageing?

Researchers will compare sirtuin activators to a placebo (a look-alike substance that contains no drug) to see if drug sirtuin activators works to improve metabolic status.

Participants will:

Take sirtuin activators or a placebo every day for 6 months. Visit the university once every 3 months for checkups and tests.

Eligibility

Primary outcome measure(s)

• Concentrations of blood lipids — 6 months, two measurements: at month 0 and 6
  Total cholesterol, Triacyglycerols, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesteroll
• Blood glucose concentrations — 6 months, two measurements: at month 0 and 6
  Blood glucose concentration
• Ageing biomarkers: transcription level of the p16INK4a gene in peripheral blood mononuclear cells — 6 months, two measurements: at month 0 and 6
  transcription level of the p16INK4a gene in peripheral blood mononuclear cells
• Ageing biomarkers: telomere lenght — 6 months, two measurements: at month 0 and 6
  telomere lenght measured in DNA isolated from whole blood
• Ageing biomarkers: SA beta galactosidase activity — 6 months, two measurements: at month 0 and 6
  SA beta galactosidase activity
• Oxidative stress — 6 months, two measurements: at month 0 and 6
  activities of oxidative stress enzymes in blood

Trial sites (1)

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