Predictive Factors and Monitoring Strategies in Steroid-Induced Diabetes

NCT07190378 · tracked via the Priya Life Science Poland tracker

Sponsor

Medical University of Warsaw

Phase

Observational

Started

2025-06-20

Last updated

2025-10-01

Condition(s) studied

Steroid-Induced DiabetesDiabete Type 2Steroid Induced Hyperglycemia

Study summary

Glucocorticoids are widely used in the management of autoimmune, inflammatory and neoplastic conditions. However, they are associated with significant metabolic effects, including steroid-induced diabetes (SID). SID is typically diagnosed using general criteria for type 2 diabetes, which may be inadequate due to the unique glycemic profile often seen in SID, where postprandial hyperglycemia predominates. This research aims to explore the diagnostic value of CGM during steroid therapy and identify risk factors for SID This is a prospective observational study (n=250) enrolling adults initiating glucocorticoid therapy. Participants will undergo 14-day continuous glucose monitoring (CGM) to assess predictive factors and glycemic profile.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Accepted

Inclusion criteria: * Adults (≥18 years of age) * No prior diagnosis of diabetes * Planned initiation of oral and/or intravenous glucocorticoid therapy for non-substitutive indications * Informed consent Exclusion criteria: * Age \<18 years * History of diabetes or use of antidiabetic medications * GC therapy within the past 6 months * Replacement therapy for primary or secondary adrenal insufficiency, pituitary insufficiency, Nelson's syndrome, or congenital adrenal hyperplasia * Lack of consent

Primary outcome measure(s)

Diagnosis of diabetes — From enrollment to the end of the observation at 2 weeks
diagnosis of steroid-induced diabetes based on fasting blood glucose 2 times above 126 mg/dl and/or HbA1c\>6.5% and/or blood glucose above 200 mg/dl

Trial sites (1)

Facility	City	Region	Status
Department of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland	Warsaw	Warsaw

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Other trials for the same condition

Evaluation of the Efficacy and Safety of GLP-1 Receptor Agonist Therapy In Steroid-Induced Diabetes Enrolling by invitation

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07190378 on ClinicalTrials.gov ↗ ← All trials in Poland