Vaccination Against Influenza Pre-discharge in Heart Failure

NCT06725927 · tracked via the Priya Life Science Poland tracker

Sponsor

Wroclaw Medical University

Phase

Phase 4

Started

2024-12-31

Last updated

2025-07-23

Condition(s) studied

Heart Failure

Investigational drug(s) / intervention(s)

Influenza vaccination →

Influenza vaccination: Influenza vaccination pre-discharge in patients hospitalized due to heart failure exacerbation

Study summary

In patients with heart failure (HF), influenza vaccination should be considered to prevent HF hospitalizations. However, vaccination rates among patients with HF are low, in part because of subjective but common concerns about whether patients with such severe disease should be vaccinated. In this randomized, open-label study, we will investigate whether influenza vaccination before discharge in patients stabilized after cardiac decompensation is safe and improves outcomes over a 6-month follow-up period.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * informed consent to participate in the study * hospitalization (unplanned) due to exacerbation (decompensation) of heart failure * planned discharge within the next 48 hours due to completion of hospital treatment * no current (2024/25 season) influenza vaccination. Exclusion Criteria: * severe post-vaccination reaction during influenza vaccination in any previous influenza season * hypersensitivity to any of the components of the vaccine planned to be administered * discharge to another hospital for continued treatment or discharge to a nursing home * antibiotic therapy among the drugs recommended for taking after hospitalization.

Primary outcome measure(s)

Primary composite endpoint - cardiovascular death, heart failure hospitalization or infection — 6 months

Trial sites (1)

Facility	City	Region	Status
Jan Mikulicz Radecki University Hospital in Wroclaw	Wroclaw	Lower Silesian Voivodeship

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06725927 on ClinicalTrials.gov ↗ ← All trials in Poland