Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)

NCT07269366 · tracked via the Priya Life Science Netherlands tracker

Sponsor

University Medical Center Groningen

Phase

Not applicable

Started

2026-05

Last updated

2026-05-12

Condition(s) studied

Coronary Artery DiseaseCoronary Artery Disease (CAD)Multivessel Coronary Artery DiseaseCABGCABG in Low EFHeart FailurePCIRevascularization

Investigational drug(s) / intervention(s)

CABGPCI

CABG: CABG (coronary artery bypass grafting)

PCI: PCI (percutaneous coronary intervention)

Study summary

This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease. The study evaluates differences in survival, major cardiovascular events, and quality of life over 4 years, and contributes to the international STICH 3.0 collaboration assessing long-term outcomes.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age ≥ 18 years * LVEF≤ 40% * Angina pectoris, CCS≥2 and/or hospitalization for ACS or heart failure within 1 year prior to randomization * Multivessel CAD (2-3 vessel-disease with coronary lesions \>70% and involvement of proximal LAD, and/or LM stenosis of \>50%). Target vessels are determined by the local Heart Time * Clinical and angiographical characteristics suitable for isolated coronary revascularization both by CABG or PCI according to the judgment of the local Heart Team * Written informed consent Exclusion Criteria: * ACS \< 48 hours before randomization * Valvular/structural heart disease requiring intervention * Contra-indications to DAPT * Non-cardiac condition with life expectancy \< 1 year * Previous CABG * Decompensated HF at the time of inclusion

Primary outcome measure(s)

Hierarchical composite of all-cause mortality, major adverse cardiovascular events, and heart failure hospitalizations — 4 years
Outcomes will be analyzed using a hierarchical (win ratio / Finkelstein-Schoenfeld) approach to account for clinical severity

Trial sites (1)

Facility	City	Region	Status
University Medical Center Groningen	Groningen	Netherlands	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07269366 on ClinicalTrials.gov ↗ ← All trials in the Netherlands