Effect of High-intensity Interval Training on Cardiometabolic Health and Physical Fitness in Young Adults With Obesity

Condition(s) studied

Investigational drug(s) / intervention(s)

High-intensity interval training intervention: The HIIT group will undergo training for 12 weeks, with a frequency of three sessions per week, completing a total of 36 sessions. Each session will include a 5-minute warm-up and a 5-minute cool-down at 50-60% of maximum heart rate (HRmax). The training protocol will consist of 2-minute high-intensity intervals performed at 90-95% HRmax, corresponding to a Borg rating of perceived exertion (RPE) of 17-18, alternated with 2-minute recovery periods at 70% HRmax (RPE 12-14). A total of five intervals will be completed per session, resulting in an overall high-intensity workload of 18 minutes. All training sessions will be conducted on a stationary cycle ergometer

Moderate-intensity continuous training intervention: The MICT group will perform moderate-intensity continuous training at 60-70% HRmax, corresponding to an RPE of 12-14, for 35-45 minutes on a stationary cycleergometer. Heart rate and physical activity levels will be continuously monitored in both groups using a chest-strap heart rate sensor (Polar H9, Polar Electro, Finland).

Educational sessions: In addition, four educational sessions will be conducted to provide dietary recommendations to all participants. These sessions will aim to promote balanced eating habits and to discourage the excessive consumption of ultra-processed foods or alcohol, as these factors could interfere with the intervention outcomes.

Study summary

The objective of the present project is to compare the effects of two types of training on cardiovascular health components and physical fitness in young adults with obesity.

Eligibility

Primary outcome measure(s)

• Maximum oxygen uptake (VO₂max) — Baseline and after 12 weeks
  VO₂max (ml/min/kg): Change from Baseline at 12 weeks, measured using a submaximal exercise test based on the Åstrand-Ryhming protocol
• Weight — Baseline and after 12 weeks
  Weight (kg): Changes in weight from baseline to 12 weeks of intervention.
• Height — Baseline and after 12 weeks
  Height (cm): Changes in height from baseline to 12 weeks of intervention.
• Body mass index (BMI) — Baseline and after 12 weeks
  BMI (kg/m2): Change from Baseline at 12 weeks, calculated by: weight (kg)/ height (m\^2)
• Body fat percentage — Baseline and after 12 weeks
  Body fat percentage (%): Changes in body fat assessed by bioelectrical impedance analysis (BIA)
• Muscle mass percentage — Baseline and after 12 weeks
  Muscle mass percentage (%): Changes in muscle mass measured using bioelectrical impedance analysis (BIA)
• Waist circumference — Baseline and after 12 weeks
  Waist circumference (cm): Changes in waist circumference will be measured using a Lufkin measuring tape (USA) following the guidelines of the International Society for the Advancement of Kinanthropometry (ISAK)
• Waist-to-hip ratio — Baseline and after 12 weeks
  Waist-to-hip ratio: Changes in waist-to-hip ratio will be calculated by dividing the waist measurement by the hip measurement
• Glucose — Baseline and after 12 weeks
  Glucose (mg/dl): Changes from baseline to 12 weeks of intervention
• Triglycerides — Baseline and after 12 weeks
  Triglycerides (mg/dl): Changes from baseline to 12 weeks of intervention
• Total cholesterol — Baseline and after 12 weeks
  Total cholesterol (mg/dl): Changes from baseline to 12 weeks of intervention
• HDL cholesterol — Baseline and after 12 weeks
  HDL cholesterol (mg/dl): Changes from baseline to 12 weeks of intervention
• LDL cholesterol — Baseline and after 12 weeks
  LDL cholesterol (mg/dl): Changes from baseline to 12 weeks of intervention
• C-reactive protein (CRP) — Baseline and after 12 weeks
  CRP (mg/dl): Changes from baseline to 12 weeks of intervention
• Systolic blood pressure (SBP) — Baseline and after 12 weeks
  SBP (mmHg): Changes from baseline to 12 weeks of intervention
• Diastolic blood pressure (DBP) — Baseline and after 12 weeks
  DBP (mmHg): Changes from baseline to 12 weeks of intervention

Trial sites (1)

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