Type 2 Diabetes and Associated Factors in Mexico

Condition(s) studied

Investigational drug(s) / intervention(s)

Clinical and Molecular Assessment: Participants underwent clinical examination, lifestyle and dietary questionnaires, functional testing (six-minute walk test), and blood sampling for biochemical and transcriptomic analysis.

Study summary

The goal of this observational cross-sectional multicenter study is to identify clinical, lifestyle, metabolic, inflammatory, and genetic factors associated with glycemic control and complications of Type 2 Diabetes (T2D) in adult patients in Mexico.

The main questions it aims to answer are:

Which molecular and clinical factors are associated with poor glycemic control (HbA1c \> 7%)?

Which factors are linked to the presence of diabetic nephropathy (GFR \< 60 mL/min/1.73 m²)?

Participants:

Provide informed consent and clinical history.

Undergo a clinical and physical evaluation (including six-minute walk test).

Complete lifestyle, dietary, and therapeutic adherence questionnaires.

Provide blood samples for biochemical, inflammatory, and transcriptomic (RNA-Seq) analysis.

Researchers integrate clinical, biochemical, and transcriptomic data using statistical modeling to identify a characteristic molecular fingerprint of poor metabolic control and diabetes-related complications.

Eligibility

Primary outcome measure(s)

• Glycemic control (% HbA1c) — At baseline (single cross-sectional assessment).
  Proportion of participants with poor glycemic control, defined as HbA1c \> 7%.
• Diabetic Nephropathy (eGFR) — At baseline (single cross-sectional assessment).
  Presence of diabetic nephropathy defined as estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73 m².

Trial sites (3)

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