Screening: Annual LDCT, lung function test (spirometry), anxiety/depression assessments, and serum biomarkers tests over 3 years. Follow-up will continue for 5 and 10 years or until event completion (cancer diagnosis, end of follow-up, or death).
Study summary
This prospective study aims to detect early-stage lung cancer using low-dose computed tomography (LDCT) in Mexicans aged 50 or older who are current or former heavy smokers, non-smokers exposed to significant wood smoke, or diagnosed with COPD. Annual LDCT, spirometry, and serum biomarker tests will be conducted over 3 years, and a follow-up lasting up to 10 years.
Eligibility
Sex
ALL
Min age
50 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
Eligible participants over fifty years old and one of the next criteria:
* Current smokers (\>20 pack-years)
* Former smokers (\>20 pack-years) who have quit within the past 15 years,
* Non-smokers exposed to wood smoke more than 100 hours/year
* Patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD).
Exclusion Criteria:
* Subjects who cannot be examined by tomography due to physical limitations such as weight.
* History of any type of cancer within the last five years, except non-melanoma skin cancer.
* Symptoms consistent with some malignant neoplasm.
* People with a poor physical-emotional condition that reduces their life expectancy or does not ensure adherence to the study.
Elimination Criteria
• Withdrawal of informed consent
Primary outcome measure(s)
Lung cancer incidence in Mexican population — Annually over 3-year from inclusion Assess the number of lung cancer detections after each round of screening.
Trial sites (1)
Facility
City
Region
Status
Instituto Nacional de Cancerologia (INCan) Mexico
Mexico City
Tlalpan
Recruiting
More Instituto Nacional de Cancerologia de Mexico trials in Mexico
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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