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Clinical Trials in Mexico / NCT03768063
Active, not recruiting Phase 3

A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study

NCT03768063 · tracked via the Priya Life Science Mexico tracker
Phase
Phase 3
Started
2019-02-28
Last updated
2026-07-24

Condition(s) studied

Cancer

Investigational drug(s) / intervention(s)

Atezolizumab →Bevacizumab →Alectinib →Cobimetinib →Vemurafenib →FAP IL2VVenetoclax →Enzalutamide →Pembrolizumab →Sunitinib →Niraparib →Cabozantinib →Pemetrexed →Paclitaxel →Emactuzumab →Rucaparib →

Atezolizumab: Atezolizumab will be administered as a monotherapy or atezolizumab with other agent(s) as per parent protocol. Dosing regimen will continue in accordance with the parent study or at equivalent dose (if applicable) and at the same schedule as the parent study, or switch to a fixed atezolizumab dose of 1200 mg every 3 weeks (Q3W).

Bevacizumab: Bevacizumab will be administered as directed per the parent study.

Alectinib: Alectinib will be administered as directed per the parent study.

Cobimetinib: Cobimetinib will be administered as directed per the parent study.

Vemurafenib: Vemurafenib will be administered as directed per the parent study.

FAP IL2V: FAP IL2V will be administered as directed per the parent study.

Venetoclax: Venetoclax will be administered as directed per the parent study.

Enzalutamide: Enzalutamide will be administered as directed per the parent study.

Pembrolizumab: Pembrolizumab will be administered as directed per the parent study.

Sunitinib: Sunitinib will be administered as directed per the parent study.

Niraparib: Niraparib will be administered as directed per the parent study.

Cabozantinib: Cabozantinib will be administered as directed per the parent study.

Pemetrexed: Pemetrexed will be administered as directed per the parent study.

Paclitaxel: Paclitaxel will be administered as directed per the parent study.

Emactuzumab: Emactuzumab will be administered as directed per the parent study.

Rucaparib: Rucaparib will be administered as directed per the parent study.

Study summary

This is an open-label, multicenter, extension study. Patients who are receiving clinical benefit from atezolizumab monotherapy or atezolizumab in combination with other agent(s) or combination/comparator agent(s) during participation in a Genentech or Roche-sponsored study (the parent study), who are eligible to continue treatment and who do not have access to the study treatment locally, may continue to receive study treatment in this extension study following roll-over from the parent study.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Eligible for continuing atezolizumab-based therapy at the time of roll-over from the parent study, as per the parent study protocol or * Eligible for continuing the comparator agent(s) in a Genentech- or Roche-sponsored study as per the parent study protocol, with no access to commercially available comparator agent * Time between the last dose of treatment received in parent study and first dose in extension study is no longer than the interruption period allowed in the parent study. First dose of study treatment in this extension study will be received within 7 days of the treatment interruption window allowed by the parent study * Continue to benefit from atezolizumab-based study treatment or from the comparator at the time of roll-over from the parent study as assessed by the investigator * Negative serum pregnancy test within 7 days prior to start of study treatment in women of childbearing potential * For women of childbearing potential: agreement to remain abstinent or use contraceptive methods, and agreement to refrain from donating eggs * For men: agreement to remain abstinent or use contraceptive measures, and agreement to refrain from donating sperm Exclusion Criteria: * Meet any of the study treatment discontinuation criteria specified in the parent study at the time of enrollment in this extension study * Study treatment or comparator agent is commercially marketed in the patient's country for the patient-specific disease and is accessible to the patient * Treatment with any anti-cancer treatment during the time between last treatment in the parent study and the first dose of study treatment in this extension study * Permanent discontinuation of atezolizumab for any reason during the parent study or during the time between last treatment in the parent study and the first dose of study treatment in this extension study (if applicable). Exception: Participants who permanently discontinued atezolizumab from parent studies that permit participants to continue treatment with the combination agent(s) alone after permanently discontinuing atezolizumab are eligible to enroll in this study. * Ongoing serious adverse event(s) that has not resolved to baseline level or Grade ≤1 from the parent study or during the time between the last treatment in the parent study and the first dose of study treatment in this extension study * Any condition that, in the opinion of the investigator, would interfere with the interpretation of patient safety or place the patient at high risk for treatment-related complications * Concurrent participation in any therapeutic clinical trial (other than the parent study) * Pregnant or lactating, or intending to become pregnant during this extension study and for the period after the last dose of study treatment specified in the designated referenced safety information (RSI)

Primary outcome measure(s)

Trial sites (80)

FacilityCityRegionStatus
University of Colorado Cancer Center Aurora Colorado
Yale University School Of Medicine Trumbull Connecticut
Massachusetts General Hospital Boston Massachusetts
Beth Israel Deaconess Medical Center Boston Massachusetts
Carolina BioOncology Institute, PLCC Huntersville North Carolina
St. Luke's Cancer Care Associates Bethlehem Pennsylvania
University of Texas Health Sciences Center in San Antonio San Antonio Texas
St Vincent'S Hospital Darlinghurst New South Wales
UZ Leuven Leuven Flemish Brabant
Institut Jules Bordet Brussels Belgium
UZ Brussel Brussels Belgium
Hospital das Clinicas - UFRGS Porto Alegre Rio Grande do Sul
Multiprofile Hospital for Active Treatment Central Onco Hospital OOD Plovdiv Bulgaria
Pontificia Universidad Catolica de Chile Santiago Chile
Masaryk?v onkologický ústav Brno Czechia
Rigshospitalet København Ø Denmark
CHU Angers Angers Pays de la Loire Region
Centre Antoine Lacassagne Nice Provence-Alpes-Côte d'Azur Region
Centre Hospitalier Régional Universitaire de Lille (CHRU) - Hôpital Claude Huriez Lille France
hopital de la Timone Marseille France
Institut Gustave Roussy Villejuif Île-de-France Region
Universitätsklinikum Ulm Ulm Baden-Wurttemberg
Krankenhaus Barmherzige Bruder Regensburg Regensburg Bavaria
Universitätsklinikum Schleswig-Holstein;Campus Lübeck Lübeck Schleswig-Holstein
Kliniken Essen-Mitte Essen Germany
Universitätsklinikum Freiburg Freiburg im Breisgau Germany
Asklepios-Fachklinik Muenchen-Gauting Gauting Germany
SRH Wald-Klinikum Gera Gera Germany
Lungenfachklinik Immenhausen Immenhausen Germany
Universitaetsklinikum Muenster Münster Germany
Universitaets-Hautklinik Tuebingen Tübingen Germany
Universitaettsklinikum Tübingen Tübingen Germany
Universitätsklinik Tübingen Tübingen Germany
Metropolitan Hospital Piraeus Attica
Laiko General Hospital Athen Athens Greece
Anticancer Hospital Ag. Savas Athens Greece
Grupo Angeles Guatemala City Guatemala
Queen Mary Hospital Hong Kong Hong Kong
Szegedi Tudományegyetem Szeged Hungary
Istituto Nazionale dei Tumori Milan Lombardy

+ 40 more sites — see the full list on the official registry below.

On this site

📄 Tecentriq (atezolizumab) drug profile → 📄 Avastin (bevacizumab) drug profile → 📄 Venclexta (venetoclax) drug profile → 📄 Xtandi (enzalutamide) drug profile → 📄 Keytruda (pembrolizumab) drug profile → 📄 Zejula (niraparib) drug profile → 📄 Cabometyx (cabozantinib) drug profile → 📄 Rubraca (rucaparib) drug profile →

More Hoffmann-La Roche trials in Mexico

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT03768063 on ClinicalTrials.gov ↗ ← All trials in Mexico