The Invictus Registry will compare the diagnostic performance of coronary computed tomography angiography (CCTA) versus intravascular imaging by intravenous ultrasound (IVUS) or optical coherence tomography (OCT) for the measurement of minimum lumen area, the identification of stenosis severity, burden, morphology and vulnerability of coronary atherosclerosis.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Signed informed consent, inclusive of release of medical information, and Health Insurance Portability and Accountability Act (HIPAA) documentation
* Age 18 years or older
* Known or suspected Coronary Artery Disease and subsequently indicated for coronary artery angiography
Exclusion Criteria:
* Individuals unable to provide informed consent
* Acute ST elevation myocardial infarction
* Pregnant woman
* Angiographically visible thrombus at the site of the lesion interrogated by IVUS or OCT
* Patients with lesions required balloon angioplasty before OCT and/or IVUS
Primary outcome measure(s)
To compare the diagnostic performance of CCTA versus IVUS or OCT for the measurement of minimum lumen area. — June 2019- June 2021 Patients will undergo invasive coronary angiography with IVUS/OCT for the measurement of minimum lumen area, the identification of stenosis severity, burden, morphology and vulnerability of coronary atherosclerosis.
The co-registration of IVUS/OCT images with CCTA segmented images will be implemented in the following three stages by locating the corresponding anatomical landmarks/fiduciary points (coronary ostia, side-branches, calcified plaques, and/or overlapping veins) and matching the corresponding coronary segments in all the imaging modalities
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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