Retrospective case-control analysisprospective case-control group
Retrospective case-control analysis: Single-center observational retrospective study with case collection starting June 2024
prospective case-control group: Single-center prospective observational study with recruitment of new cases for 30 months from the start of the project.
Study summary
This study hypothesizes that the histological, immunophenotypic, and molecular characterization of atypical endometriotic lesions may be related to specific clinical and ultrasound features.Identifying potentially atypical lesions would allow for more accurate stratification of patients, distinguishing definitely benign from potentially atypical endometriosis.
The targeted study of endometriosis, both typical and atypical, also with reference to the inflammatory microenvironment, as well as immunophenotypic and molecular characteristics, could allow the formulation of pathogenic hypotheses on the development and progression of atypia towards malignant neoplasms.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age \> 18 years
* Candidate patients for endometriosis surgery with deep endometriosis (intestine, LUS) and/or endometrioma localizations.
* Patients who are candidates for surgery for established or suspected endometrial and/or ovarian neoplasm
* Patients who have performed a level II gynecological ultrasound with an experienced operator in the preoperative process.
* Patients where there is the technical possibility of performing a transvaginal and/or transrectal ultrasound and the patient's willingness to undergo such an investigation.
* Signing of informed consent.
Exclusion Criteria:
* Technical impossibility of performing a transvaginal ultrasound (patient virgo, patient refusal).
* Previous neoplasms
* Patient who does not provide their informed consent.
Primary outcome measure(s)
Identification of specific histopathological, immunohistochemical and molecular biology features for definable "atypical", "preneoplastic" or "cancerized-neoplastic" lesions and the surrounding microenvironment — through study completion, an average of 1 year
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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