Optical Coherence Tomography assessment: assessment of the number of infiltrating macrophages
Study summary
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages.
This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients with chronic coronary artery disease;
* Patients with no-ST elevation acute coronary syndrome;
* Patients with chronic claudication (Rutherford II-III)
* Patients with critical limb ischemia (Rutherford IV-V).
Exclusion Criteria:
* Severe renal dysfunction
* Severe valve disease
* Advanced heart failure
* Advanced liver disease
* Chronic inflammatory or autoimmune disease
* Use of antinflammatory drugs
* Acute infection
* Recent surgical procedures
Primary outcome measure(s)
presence of macrophages and their activation within coronary and peripheral atherosclerotic lesions — From enrollment to hospital discharge following peripheral angiography/coronary angiography To evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions (using OCT imaging), and to correlate these findings with the distribution of circulating monocyte subpopulations.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.