Microplastics in Brain Hematomas and Neurological Outcomes After Intracerebral Hemorrhage

Condition(s) studied

Investigational drug(s) / intervention(s)

Observational Analysis: No intervention is administered as part of the study. All patients receive standard clinical care according to current guidelines for intracerebral hemorrhage. Biological samples, including intracerebral hematoma tissue and peripheral blood, are collected for observational analysis of micro- and nanoplastics and their association with clinical, radiological, and biological outcomes.

Study summary

This observational study investigates the presence of micro- and nanoplastics in surgically removed intracerebral hematomas and their association with neurological outcomes in patients with spontaneous intracerebral hemorrhage.

Microplastics have recently been identified in human tissues and are increasingly recognized as potential contributors to inflammation and vascular dysfunction. However, their role in cerebrovascular diseases, particularly intracerebral hemorrhage, remains unknown.

Patients undergoing surgical hematoma evacuation will be enrolled. Brain tissue and blood samples will be analyzed using advanced spectroscopic and imaging techniques to detect and characterize micro- and nanoplastics.

The study aims to evaluate whether the presence of these particles is associated with increased inflammation, worse neurological outcomes, and higher risk of adverse cerebrovascular events.

This research may provide novel insights into the impact of environmental pollutants on brain vascular disease and patient prognosis.

Eligibility

Primary outcome measure(s)

• Concentration of Micro- and Nanoplastics in Intracerebral Hematoma Tissue — Baseline (intraoperative sampling)
  Quantification of micro- and nanoplastics in intracerebral hematoma tissue samples collected during surgical evacuation.

Trial sites (1)

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