This study evaluates the inter-observer reliability of a standardized WB-MRI scoring system for CRMO and its consistency with the PedCNO clinical score. It also investigates whether changes in the radiologic score mirror therapeutic response, supporting a more objective clinical-radiological disease assessment.
Eligibility
Sex
ALL
Min age
—
Max age
32 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients with a diagnosis of CRMO according to the international Bristol clinical and radiologic criteria, followed at the Pediatric Rheumatology Clinic of the Pediatric Unit, IRCCS AOU Bologna, Sant'Orsola Hospital;
* Age under 18 years at the time of CRMO diagnosis;
* At least one WB-MRI performed as part of routine clinical follow-up between January 2015 and the start date of the study;
* Availability of complete clinical documentation (including reports, radiologic images, and clinical information) sufficient to apply both the WB-MRI score and the PedCNO score;
* Obtain informed consent.
Exclusion Criteria:
\- Alternative diagnoses accounting for the bone lesions (e.g., infections, neoplasms).
Primary outcome measure(s)
To assess the inter-observer reliability and reproducibility of the WB-MRI radiologic scoring system for CRMO lesions, applied independently and in a blinded manner by at least two pediatric radiologists for each WB-MRI performed in patients in with CRMO — at baseline Inter-observer agreement for each individual examination, calculated using ICC
Trial sites (1)
Facility
City
Region
Status
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna
Italy
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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