Obesity and Obesity-related Medical ConditionsCardiovascular RiskGenetics
Study summary
experimental study with analysis on tissues. This study aims to study cardiometabolic risk from a genetic, clinical, instrumental and laboratory point of view in a population of subjects with obesity.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* • Age \> 18 years
* BMI \> 30 Kg/m2
* In primary prevention for cardiovascular disease
* Ability to communicate, make themselves understood and adhere to study-specific procedures
* Willingness to participate in the study and obtain informed consent
Exclusion Criteria:
* Patients already enrolled by the Research Units involved in the enrolment
* Glycated hemoglobin level \> 55 mmol/L
* Patients suffering from obesity secondary to endocrinological diseases or iatrogenic causes
* Patients with heterozygous Familial Hypercholesterolemia (Dutch Lipid Score - DLS\>8)
* Patients suffering from hypercholesterolemia secondary to lipid or iatrogenic extra-metabolic pathologies
* Patients suffering from systemic inflammatory or oncological diseases
* Patients on active treatment with GLP-1 analogues
* Pregnancy and breastfeeding
* Any medical or surgical condition that makes the patient's adherence to the study protocol complex or inconsistent.
Primary outcome measure(s)
cycle threshold miRNAs — at baseline Study of the expression profile of specific circulating miRNAs
Presence/absence of the loss-of-function HMGA1 allelic variant (rs146052672) — baseline search for variants of the HMGA1 gene
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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