Prevalence of Ethnic Neutropenia and Duffy Null Phenotype in Neonates

Condition(s) studied

Investigational drug(s) / intervention(s)

Cord blood: Cord blood samples will be collected during routine G6PD testing. An additional 3 mL will be obtained non-invasively from the umbilical cord to determine the expression of Duffy antigens using serologic gel testing.

Study summary

This is a prospective observational study designed to assess the prevalence of the Duffy null phenotype (associated with ethnic neutropenia) in neonates born at Kaplan Medical Center. Blood samples will be collected from umbilical cords (non-invasively) to evaluate Duffy antigen expression. Data on ethnicity, perinatal factors, and routine blood counts at 9-12 months (when available) will also be collected to correlate phenotype with absolute neutrophil count (ANC).

Eligibility

Primary outcome measure(s)

• Prevalence of Duffy null phenotype in neonates — At birth (umbilical cord sample)
  Percentage of neonates born with the Duffy null phenotype (Fya-/Fyb-) as determined by serologic gel-based testing.

Trial sites (1)

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