🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Clinical Trials in Germany / NCT07781631
Recruiting Phase 1

A Study in Healthy Men to Test Whether Carbamazepine Influences the Amount of Verducatib in the Blood

NCT07781631 · tracked via the Priya Life Science Germany tracker
Phase
Phase 1
Started
2026-09-10
Last updated
2026-09-23

Condition(s) studied

Healthy

Investigational drug(s) / intervention(s)

Verducatib →Carbamazepine →

Verducatib: Verducatib

Carbamazepine: Carbamazepine

Study summary

The main objective of this trial is to investigate the effect of carbamazepine, a strong CYP3A4 inducer on the pharmacokinetics of verducatib at steady state.

Eligibility

Sex
MALE
Min age
18 Years
Max age
50 Years
Healthy volunteers
Accepted
Inclusion Criteria: 1. Healthy male trial participant according to the assessment of the Investigator, as based on a complete medical history including physical examination, vital signs (blood pressure, heart rate), 12-lead electrocardiogram, clinical laboratory tests and columbia-suicide severity rating scale (C-SSRS) 2. Age of 18 to 50 years, inclusive 3. Body mass index (BMI) of 18.5 to 29.9 kg/m2, inclusive 4. Signed and dated written informed consent in accordance with international council for harmonisation-good clinical practice (ICH-GCP) and local legislation prior to admission to the trial Exclusion Criteria: 1. Any finding in the medical examination, including blood pressure, pulse rate or electrocardiogram, as well as neurological examination and skin inspection deviating from normal and assessed as clinically relevant by the Investigator 2. Repeated measurement of systolic blood pressure outside the range of 90 to 140 mmHg, diastolic blood pressure outside the range of 50 to 90 mmHg, or pulse rate outside the range of 50 to 90 beats per minute 3. Any laboratory value outside the reference range that the Investigator considers to be of clinical relevance, particularly including but not limited to haematological parameters such as haemoglobin, serum iron, leucocyte- and platelet count, hepatic parameters such as alanine aminotransferase (ALT), aspartate aminotransfrrase (AST), gamma-glutamyl transferase (GGT) and total bilirubin or renal parameters such as e.g. creatinine at screening, electrolyte disturbances, particularly hyponatremia 4. Any evidence of a concomitant disease assessed as clinically relevant by the Investigator 5. Further exclusion criteria apply

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
CRS Clinical Research Services Berlin GmbH Berlin Germany Recruiting

More Boehringer Ingelheim trials in Germany

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07781631 on ClinicalTrials.gov ↗ ← All trials in Germany