Heterotopic Gastric Mucosa of the Proximal EsophagusGastric Inlet PatchesDysphagiaDyspepsia
Study summary
The goal of this observational study is to learn whether heterotopic gastric mucosa (HGM) in the upper esophagus is associated with swallowing difficulties (dysphagia) in adults undergoing a medically indicated gastroscopy. The main questions it aims to answer are:
* Is the presence of HGM associated with dysphagia?
* Is the presence of HGM associated with dyspepsia and reduced health-related quality of life? Among participants reporting dysphagia, what is the distribution of oropharyngeal versus esophageal dysphagia, and is this related to the presence of HGM? If there is a comparison group: Researchers will compare participants with endoscopically confirmed HGM to participants without HGM to determine whether dysphagia, dyspepsia symptoms, and quality-of-life measures differ between groups.
Participants will:
Complete pseudonymised questionnaires about dysphagia, dyspepsia symptoms, and quality of life before the gastroscopy.
Undergo the medically indicated gastroscopy as planned; the endoscopist will assess whether HGM is present based on the endoscopic appearance, and routine endoscopy findings will be documented.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Planned upper gastrointestinal endoscopy (gastroscopy) for clinical reasons (any indication)
* Age ≥ 18 years
* Written informed consent
* Ability to complete the study questionnaires prior to endoscopy
Exclusion Criteria:
* Previously known heterotopic gastric mucosa (HGM)
* Previously diagnosed dysphagia with prior therapeutic intervention (including pre-established diet modification, partial oral/enteral nutrition, steroid therapy, botulinum toxin injection, etc.)
* Mechanical ventilation
* Presence of a tracheostomy
* Inadequate endoscopic assessability of the proximal esophagus, including:
* General condition insufficient for careful endoscopic inspection (investigator's judgement)
* Increased risk of aspiration
* Inadequate visibility during the procedure (e.g., bleeding, food residue)
* Complications preventing careful inspection of the proximal esophagus
* History of surgery involving the pharynx or esophagus
* Relevant severe neurological disorder (e.g., ALS, stroke)
* Severe dementia
* Severe depressive disorder
* Lack of cooperation / inability to comply with study procedures
* Planned PEG placement
* Emergency endoscopy
Primary outcome measure(s)
Dysphagia Symptom Burdon (EAT-10 und SSQ) — Baseline (prior to gastroscopy; single assessment at enrollment) Dysphagia symptom burden is assessed using two patient-reported questionnaires completed prior to medically indicated gastroscopy: (1) the Sydney Swallow Questionnaire (SSQ/SSQ-G) and (2) the Eating Assessment Tool-10 (EAT-10). The SSQ total score ranges from 0 to 1700 (higher scores indicate worse swallowing-related symptoms); for descriptive/binary analyses, an SSQ-G total score \>234 is considered outside the normative range (pathological). The EAT-10 total score ranges from 0 to 40 (10 items scored 0-4; higher scores indicate greater dysphagia burden); an EAT-10 total score ≥3 is considered abnormal (indicative of dysphagia). Comparative analyses will be performed between participants with endoscopically detected heterotopic gastric mucosa (HGM) and participants without HGM.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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