Topical Application of PRF Before Radiation Therapy

NCT06406530 · tracked via the Priya Life Science Germany tracker

Sponsor

University of Giessen

Phase

Not applicable

Started

2023-12-01

Last updated

2025-04-11

Condition(s) studied

PRF

Investigational drug(s) / intervention(s)

PRFNatural Healing

PRF: Patients blood is standardized centrifuged and split in to a red-phase (erythrocytes) and white-phase (PRF). The gained PRF is processed to a clot-fort and is inserted into the alveolus.

Natural Healing: After the tooth extraction, natural healing is aimed by allowing a blood clot formation without any further intervention.

Study summary

The primary goal of this study is to observe whether PRP promotes the wound healing before a radiation therapy or not, compared to the natural healing of a tooth extraction socket.

Secondary aim is to monitore the effect on the pain perception.

Eligibility

Sex

ALL

Min age

18 Years

Max age

99 Years

Healthy volunteers

Inclusion Criteria: * Head and neck cancer with planed radiation therapy * Bilateral tooth extraction * Similar tooth size * Atraumatic tooth extractions without flap surgery * Patients age above 18y of age Exclusion Criteria: * Prior radiation therapy in the head and neck area * Prior and current therapy with bisphosphonates or equivalent modern biologics * Patients during pregnancy or breastfeeding

Primary outcome measure(s)

Wound healing between the two sites using the Wound Healing Index — around 4 Weeks
To compare the wound heeling, a modified Landry and Turnbull Healing Index is used. This index varies from 0 to 5, where 0 means no healing and 5 excellent healing.

Trial sites (1)

Facility	City	Region	Status
University of Giessen	Giessen	Hesse	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06406530 on ClinicalTrials.gov ↗ ← All trials in Germany