In this study the investigators hypothesize that pathological alterations in adipose tissue biology already occur during the development and progression of obesity in children and adolescents. The investigators aim to identify and characterize mechanisms and molecular targets that affect the development of adipose tissue and ensuing obesity in childhood and adolescence.
Eligibility
Sex
ALL
Min age
—
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* body weight: 3000 g - 180 kg
* suitable surgical procedure
* signed informed consent by the guardians and the study participant, if older 12 years
Exclusion Criteria:
* severe chronic and inflammatory diseases
* acute or chronic infections
* oncological diseases
* clotting disorders
* complications during surgical procedure
* drug treatment
* nil by mouth
Primary outcome measure(s)
Adipose tissue dysfunction — 10 years Adipose tissue dysfunction is assessed by evaluation of adipocyte size and number (hypertrophy vs. hyperplasia), adipocyte proliferation and differentiation, (lipid) cellular metabolism, inflammation, gene expression, fibrosis, and others; the association of AT dysfunction with clincial phenotype will be assessed
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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