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Clinical Trials in France / NCT07163858
Recruiting Not applicable

Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery

NCT07163858 · tracked via the Priya Life Science France tracker
Sponsor
Infirmerie Protestante de Lyon
Phase
Not applicable
Started
2025-10-06
Last updated
2025-12-03

Condition(s) studied

Coronary Artery Disease With Need for Bypass SurgeryCoronary Artery Disease(CAD)Coronary Artery BypassOff Pump Coronary Artery Bypass GraftOff Pump Coronary Artery Bypass SurgeryHemodynamic ManagementHemodynamic OptimizationNoradrenaline

Investigational drug(s) / intervention(s)

passive leg raising for hemodynamic management during open-heart coronary bypass graftingUse of Noradrenaline only in control group

passive leg raising for hemodynamic management during open-heart coronary bypass grafting: Passive leg raising will be used in the experimental group in order to manage hemodynamics: legs will be raised to an angle of approx. 45°

Use of Noradrenaline only in control group: Noradrenaline will be used for hemodynamic management. Passive leg raising will not be used in this group

Study summary

This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass graft (CABG) surgery.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Adult patient * patient requiring isolated coronary bypass surgery * Elective procedure or medical emergency * First cardiac surgery * Patient with an EF ≥30% * Mandatory affiliation to a social security system * Signed informed consent form * Suspension of renin-angiotensin system inhibitors and angiontensn-neprilysin receptor blockers and sartans the day before surgical procedure Exclusion Criteria: * Contraindication to an inotropic substance (only NA will be used) * Contraindication to passive leg raising * Patient in a life-threatening emergency * History of cardiac surgery * Bilateral iliac or common femoral artery occlusion * EF \< 30% * Pregnancy and breastfeeding * Renal failure (GFR \< 40 ml/min/1.73 m²) * Patient with bilateral thigh amputation * Class III obesity BMI \> 40 kg/m²

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Infirmerie Protestante de Lyon Caluire-et-Cuire Auvergne-Rhône-Alpes Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07163858 on ClinicalTrials.gov ↗ ← All trials in France