Biospecimen: * 1 or 2 tumoral specimen (depending on the size of the tumor)
* 1 specimen of the healthy oral mucosa
* 1 leucoplakia specimen if applicable.
The biospecimens will be collected at the time of the surgery organised for the standard routine medical care.
Blood sampling: Blood sampling (6 mL), taken from a routine biological exam.
Study summary
The goal of this project is to characterise the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and leucoplasic) counterparts by scRNAseq in OSCC patients.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* I1. Male or female at least 18 years old.
* I2. Patient with OSCC and undergoing surgery at the Centre Léon Bérard.
* I3. Patient who has agreed to participate in this research and sign consent.
* I4. Patient affiliated to a medical insurance.
Exclusion Criteria:
* NI1. Pregnant or nursing woman.
* NI2. Contraindication to general anesthesia.
* NI3. Suspicion of rare tumor of particular histology other than squamous cell carcinoma (Sarcoma...).
* NI4. Patient under curatorial or guardianship or placed under the protection of justice.
Primary outcome measure(s)
Characterization of the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and leucoplasic) counterparts by scRNAseq in OSCC patients. — 3 years Transcriptomic data from scRNAseq for all cell populations
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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