FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort

Condition(s) studied

Investigational drug(s) / intervention(s)

Blood and urine samples: Blood and urine samples

Blood samples: Blood samples

Cardiovascular assessment: Echocardiography, Lung ultrasound, pulse wave velocity, carotid stiffness and thickness, Central and peripheral blood pressure, carotid pulse pressure, abdominal aorta ultrasound, jugular vein ultrasound, liver elastography (Optional).

Dietary intake: Food frequency questionnaires, ''Dutch eating behaviour questionnaire'' and dietary supplement questionnaire

Anthropometric parameters: Measurement of height, weight, abdominal circumference, hip circumference, arm circumference

Hemodynamic parameters: Systolic pressure index measurement

Hemodynamic parameters: Heart rate measurements, blood pressure measurements, orthostatic BP measurements

Hemodynamic parameters: Blood pressure measurements by "unattended BP" monitor over 5 min

Hemodynamic parameters: Electrocardiogram

Assessment of compliance with antihypertensive treatments for treated participants: EVALOBS scale and compliance questionnaire

Ambulatory 24 hours measurment of blood pressure: For the first 100 patients willing to participate

24 hours urinary collection: For the first 100 patients willing to participate. For biobank constitution and measurement of microalbuminuria, creatininuria, osmolarity, natriuresis, kaliuresis, urea, proteinuria and urine dipstick

General questionnaires: Collection of socio-demographic data such as age, level of education, profession, household income, smoking status, physical activity, perception of health, prematurity, height and weight at birth, family and personal history especially cardiovascular (history of stroke, myocardial infarction, heart failure, current pathologies, drugs, tobacco...)

Women specific questionnaire: Women specific questionnaire

Women specific questionnaire: Women specific questionnaire

NYHA dyspnea questionnaire: Determination of NYHA class.

Anxiety questionnaire: Assessment of anxiety

Epworth Sleepiness Scale: sleep quality assessment

A questionnaire on the "perception of the management of cardiovascular risk factors": Patient's evaluation of cardiovascular risk factors by the health system

A questionnaire on eating behaviors: Assessment of eating behaviors

A questionnaire on eating habits to determine consumer profiles: Assessement of eating habit to create a consumer profile

A questionnaire on food supplements use: Evaluation od food supplements intake

SARS-CoV-2 Infection Questionnaire: SARS-CoV-2 Infection Questionnaire

Instantaneous expired air analysis: Carbon monoxyde analysis in expired air

Capillary sampling: Capillary sampling for pollutant analysis (Optional)

Study summary

The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for Preventive Medicine of Nancy. This cohort was established with the primary objective of investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases. The 5th visit of the STANISLAS Cohort will allow a better evaluation of the cardiovascular ageing of the population and the transition toward cardiovascular or renal diseases in relation with their genetic profile and environment.

Eligibility

Primary outcome measure(s)

• Indexed left ventricular mass measured by echocardiography — Baseline
• Left ventricular volume measured by echocardiography — Baseline
• Tissue doppler imaging e' wave measured by echocardiography — Baseline
• Ratio E/e' measured by echocardiography — Baseline
• Left atrial volume measured by echocardiography — Baseline
• Pulmonary congestion evaluated by lung ultrasound — Baseline
• Pulse wave velocity measured by Sphygmocor and Complior Analyse — Baseline
• Carotid intima media thickness measured by echotracking — Baseline
• Central blood pressure — Baseline

Trial sites (1)

More Central Hospital, Nancy, France trials in France

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