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Clinical trial register · European Union · CTIS

Clinical Trials in Netherlands

The most recently authorised trials on the EU Clinical Trials Information System (CTIS), the single register for every trial run under the EU Clinical Trials Regulation (536/2014). CTIS holds a far larger historical archive than any one list can usefully show โ€” this register states both numbers rather than picking one.

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Source: EMA Clinical Trials Information System (CTIS). Showing the 2500 most recently authorised of 12445 total CTIS records โ€” a stated recency window, not the full historical archive. Synced 20 Sep 2026, 03:17 UTC
2500
Shown in this register
most recently authorised
12,445
Total on CTIS
full historical archive
745
Phase III
within the shown window
Top member states
Spain 1023 France 890 Germany 861 Italy 742 Poland 581 Netherlands 524
Narrow the registerReset
Phase
Phase I 558 Phase I/II 214 Phase II 726 Phase III 745 Phase IV 257
Lead sponsor
AstraZeneca AB 60 Assistance Publique Hopitaux De Paris 49 Merck Sharp & Dohme LLC 48 Pfizer Inc. 45 Novo Nordisk A/S 42
Member state
Spain 1023 France 890 Germany 861 Italy 742 Poland 581 Netherlands 524 Belgium 426 Czechia 327
All 28 states
29 of 2500 shown studies
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Phase
Study
Lead sponsor
Area
Member states
Decision
Phase IV
Optimization of Dupilumab Maintenance Dosing in Eosinophilic Esophagitis: A Phase IV, Randomized, Controlled, Single-Blind, Non-Inferiority Study
2026-526348-11-01Eosinophilic Esophagitis
Amsterdam UMC Stichting
Digestive System Diseases
Netherlands
01/09/2026
Phase IV
VATS or Intrapleural Enzymatic Therapy for patientS with empyema (the VIETS trial)
2026-526289-25-00Parapneumonic pleural infection/pleural empyema
Amsterdam UMC Stichting
Therapeutics
Netherlands
24/07/2026
Phase IV
Do GLP-1 based therapies improve the immunological response to vaccination in diabetes?
2026-525909-13-00Diabetes
Radboud universitair medisch centrum Stichting
Immune System Diseases
Netherlands
22/07/2026
Phase IV
Progesterone Luteal Support in Unexplained Infertility Management (PLUIM study)
2026-525747-33-00unexplained subfertillity, infertillity
Universitair Medisch Centrum Utrecht
Reproductive and Urinary Physiological Phenomena
Netherlands
30/06/2026
Phase IV
Sample Collection Study to Monitor the Risk of Malignancy Due to Insertional Oncogenesis in Early Onset Patients with Metachromatic Leukodystrophy Treated with OTL-200 in the Clinical Development Program
2025-522275-28-00Metachromatic leukodystrophy
Orchard Therapeutics (Europe) Limited
Musculoskeletal Diseases
Netherlands, Germany, Italy, Sweden, France
22/06/2026
Phase IV
Tacrolimus as prophylaxis of post-ERCP pancreatitis: a DPSG (Dutch Pancreatitis Study Group) multicenter, double-blind, randomized, placebo-controlled study.
2025-522900-26-00Post-ERCP Pancreatitis
Amsterdam UMC Stichting
Digestive System Diseases
Netherlands
19/06/2026
Phase IV
DISCO-RA:DIScontinuation of COncomitant disease modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis patients also using TNF inhibitors - a randomized long-term non-inferiority strategy trial
2026-525316-33-00Rheumatoid arthritis
Sint Maartenskliniek Stichting
Immune System Diseases
Netherlands
09/06/2026
Phase IV
BIOlogical treatment GRAdual Interval Longing in severe Asthma (BIO-GRAIL)
2025-524741-28-00Severe Asthma
Amsterdam UMC Stichting
Respiratory Tract Diseases
Netherlands
05/06/2026
Phase IV
PROTECx - Pembrolizumab Registry for Outcomes and Treatment Evaluation in Cervical Cancer
2025-522883-34-00Metastatic cervical cancer
Universitair Medisch Centrum Groningen
Neoplasms
Netherlands
11/05/2026
Phase IV
MERCURE study: MEthotrexate in ReCurrent dVIN
2025-524373-17-00dVIN caused by Lichen Sclerosus
Amsterdam UMC Stichting
Skin and Connective Tissue Diseases
Netherlands
28/04/2026
Phase IV
Methotrexate in paediatric and adolescent Crohnโ€™s disease: an observational study
2025-524129-42-00Crohnโ€™s disease
Amsterdam UMC Stichting
Digestive System Diseases
Netherlands
11/04/2026
Phase IV
Standard dosed abiraterone versus Therapeutic Drug Monitoring guided abiraterone dosing โ€“ The Adapt Abi trial
2025-524440-35-00metastatic castration resistant prostate cancer (mCRPC)
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Neoplasms
Netherlands
07/04/2026
Phase IV
Healing Diabetic Foot Ulcers with Semaglutide
2025-524738-24-00Diabetic foot ulcer
Radboud universitair medisch centrum Stichting
Cardiovascular Diseases
Netherlands
30/03/2026
Phase IV
Cholesterol lowering with atorvastatine for the prevention of gallstones following bariatric surgery (CHOLSTONE): an investigator- blinded randomised controlled trial
2025-524191-38-00Gallstones (chole(cysto)lithiasis) following bariatric surgโ€ฆ
Spaarne Gasthuis Stichting
Nutritional and Metabolic Diseases
Netherlands
17/03/2026
Phase IV
Impact Of Upadacitinib On The Frequency Of Acute Recurrent Anterior Uveitis In Patients With Axial Spondyloarthritis (UP-FOR-U)
2025-522118-21-00Axial Spondyloarthritis, Acute Anterior Uveitis
Care Arthritis Ltd.
Eye Diseases
Spain, Poland, Netherlands, France, Bulgaria, Germany
13/03/2026
Phase IV
CANIDIAP; CANagliflozin In DIAlysis Patients
2025-522742-46-00Chronic Kidney disease
Universitair Medisch Centrum Groningen
Not possible to specify
Netherlands
23/02/2026
Phase IV
The efficacy of pipamperone and aripiprazole on behaviors that challenge in people with intellectual disabilities: A series of N-of-1 cross-over trials
2024-519833-51-00Behaviors that challenge
Stichting GGZ Drenthe
Behavioral Disciplines and Activities
Netherlands
28/01/2026
Phase IV
Intrathecal baclofen pump versus selective dorsal rhizotomy for non-ambulatory children with cerebral palsy
2024-518822-33-01Cerebral Palsy
UZ Leuven
Nervous System Diseases
Netherlands, Belgium
27/01/2026
Phase IV
Assessing residual inflammation and macrophage presence in lupus nephritis after 3 months of intensified treatment with prednisolone, mycofenolate mofetil and voclosporin as compared to mycofenolate mofetil and prednisolone: an open label randomized controlled trial (MAPLE study)
2025-522187-32-01Lupus Nephritis
Amsterdam UMC Stichting
Immune System Diseases
Netherlands
15/12/2025
Phase IV
The effect of transdermal 17-ฮฒ-estradiol/progesterone supplementation on glucose regulation in peri- and postmenopausal women with type 1 and type 2 diabetes
2025-523214-83-00Diabetes Mellitus, (peri) Menopause
Amsterdam UMC Stichting
Hormonal diseases
Netherlands
15/12/2025
Phase IV
Rapid sequence emergence of general Anaesthesia
2024-516415-24-03General anesthesia
Stichting Radboud universitair medisch centrum
Anesthesia and Analgesia
Netherlands
02/12/2025
Phase IV
Optimization of pain management for acute renal colic in the Emergency Department โ€“ The OPTIMIZED trial
2025-521316-19-00Urolithiasis
Leids Universitair Medisch Centrum (LUMC)
Anesthesia and Analgesia
Netherlands
21/11/2025
Phase IV
Long-term muscle synthetic effects of intradialytic parenteral nutrition in chronic hemodialysis patients
2025-522111-42-02muscle protein turnover hemodialysis
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Nutritional and Metabolic Diseases
Netherlands
27/10/2025
Phase IV
ENDO-67 project: Investigating ENDOcrine therapy-related questions using Ki67 changes in the window-of-opportunity before breast surgery
2025-521385-10-00Breast cancer
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Neoplasms
Netherlands
21/10/2025
Phase IV
MetAddon: Methadone as co-analgesic for patients with metastatic bone pain: a double-blind randomized controlled trial
2025-522710-22-00Cancer, bone metastasis, pain
Universiteit Maastricht
Neoplasms
Netherlands
20/10/2025
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Priya Life Science (2026). EU Clinical Trials Register (CTIS), filtered. Derived from the EMA Clinical Trials Information System. Retrieved 20 September 2026. https://priyalifescience.com/clinical-trials-europe/country/netherlands

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Listing here is informational and not medical advice; eligibility is determined by each study team. Looking for Irish sites? See the Ireland, UK or USA registers. For approved medicines, see the EMA Approvals Tracker.