๐Ÿ‡ฎ๐Ÿ‡ชIreland
16ยฐC Partly Cloudy ยท Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Priya Life Science Clinical trial register
TrackersDrugsComparisonsAPI
Trackers› Clinical trials› Major depressive disorder
Clinical trial register · European Union · CTIS

Major depressive disorder Clinical Trials in the EU, 2026

The most recently authorised trials on the EU Clinical Trials Information System (CTIS), the single register for every trial run under the EU Clinical Trials Regulation (536/2014). CTIS holds a far larger historical archive than any one list can usefully show โ€” this register states both numbers rather than picking one.

Download CSV
Source: EMA Clinical Trials Information System (CTIS). Showing the 2500 most recently authorised of 12490 total CTIS records โ€” a stated recency window, not the full historical archive. Synced 25 Sep 2026, 03:16 UTC
2500
Shown in this register
most recently authorised
12,490
Total on CTIS
full historical archive
741
Phase III
within the shown window
Top member states
Spain 1016 France 881 Germany 860 Italy 735 Poland 585 Netherlands 531
Narrow the registerReset

Trials for Major depressive disorder

10 of 2500 shown studies
Download
Phase
Study
Lead sponsor
Area
Member states
Decision
Phase II
The Role of Serotonin 4 Receptor Agonism in Regulating Mood and Cognition in Depression in women (RECAP-D)
2026-526685-25-00Major depressive disorder
Region Hovedstaden
Mental Disorders
Denmark
17/09/2026
Phase II
A Randomized, Delayed-Treatment Controlled, Phase 2 Pilot Study of Manualized MDMA-Assisted Therapy for Young Adults with Chronic Treatment-Resistant Major Depressive Disorder
2024-520319-42-01Major Depressive Disorder
Ostfold Hospital Trust
Psychological Phenomena
Norway
03/07/2026
Phase IV
Unprescribing the Pill to Reassess Symptom and Cognitive Recovery in Depression (UNPRESCRIB-D)
2026-526314-90-00Major Depressive Disorder
Region Hovedstaden
Mental Disorders
Denmark
29/06/2026
Phase II
Antidepressant effects of psilocybin in the absence of serotoninergic psychedelic experience: a dimensional functional neuroimaging approach
2025-521690-14-00Major depressive disorder
Fundacio Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau
Mental Disorders
Spain
04/05/2026
Phase III
A Multicenter, Open-label, Long-term, Safety, Tolerability, and Efficacy Study of Azetukalner in Major Depressive Disorder
2025-523618-10-00Major Depressive Disorder
Xenon Pharmaceuticals Inc.
Mental Disorders
Finland, Poland, Romania, Slovakia, Spain, Germany
30/03/2026
Phase II
A Phase 2 Double-blind, Randomised, Placebo-controlled Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of DT-101 in Adults with Major Depressive Disorder
2025-522784-15-00Major Depressive Disorder
Draig Therapeutics Limited
Mental Disorders
Czechia, Bulgaria, Poland
24/02/2026
Phase III
A Phase 3, Randomized, Double-blind, Placebo-Controlled, Multicenter Study to Evaluate Azetukalner in Moderate-to-Severe Major Depressive Disorder
2025-523202-32-00Major Depressive Disorder
Xenon Pharmaceuticals Inc.
Mental Disorders
Spain, Czechia, Slovakia, Romania, Poland, Finland, Germany
26/01/2026
Phase III
NBI-1065845-MDD3027: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Maintenance of Effect of NBI 1065845 as an Adjunctive Treatment in Subjects with Major Depressive Disorder (MDD)
2025-520541-72-00Major Depressive Disorder
Neurocrine Biosciences Inc.
Mental Disorders
Bulgaria, Estonia, Poland, Italy, Spain
16/09/2025
Rows per page Showing 1–10 of 10
1
Cite this view

Priya Life Science (2026). EU Clinical Trials Register (CTIS), filtered. Derived from the EMA Clinical Trials Information System. Retrieved 25 September 2026. https://priyalifescience.com/clinical-trials-europe/condition/major-depressive-disorder

Query this register directly
GET /api/export.php?register=trials-eu&format=json Try it now →

About this register

This register is built from the EU Clinical Trials Information System (CTIS), run by the European Medicines Agency: the single register for every trial authorised under the EU Clinical Trials Regulation (536/2014). CTIS held 12,490 trial records at the last sync on 25 Sep 2026, 03:16 UTC; this register shows the 2,500 most recently authorised of them, a stated recency window rather than the full archive. The list can be downloaded as CSV or JSON.

This page shows the 10 of those trials with a site in Major depressive disorder.

How many recently authorised EU trials have a site in Major depressive disorder?

10 of the 2,500 most recently authorised trials in this register list a site in Major depressive disorder; 4 of them are Phase III. Trials are counted by authorisation on CTIS, not by recruitment status, which CTIS does not publish in the same form as ClinicalTrials.gov.

Summary by phase

Trials by phase (Major depressive disorder), 10 trials
PhaseTrialsShare
Phase II550%
Phase III440%
Phase IV110%

Most active sponsors

Lead sponsors with the most trials (Major depressive disorder)
Lead sponsorTrials
Region Hovedstaden2
Xenon Pharmaceuticals Inc.2
Draig Therapeutics Limited1
Fundacio Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau1
Janssen Cilag International1
Neurocrine Biosciences Inc.1
Ostfold Hospital Trust1
Region Skane1
Listing here is informational and not medical advice; eligibility is determined by each study team. Looking for Irish sites? See the Ireland, UK or USA registers. For approved medicines, see the EMA Approvals Tracker.