Routine Versus Selective Ureterolysis During Total Laparoscopic Hysterectomy for Benign Conditions

NCT07774871 · tracked via the Priya Life Science Egypt tracker

Sponsor

ClinAmygate

Phase

Not applicable

Started

2026-08-21

Last updated

2026-08-19

Condition(s) studied

Total Laparoscopic Hysterectomy

Investigational drug(s) / intervention(s)

Routine UreterolysisSelective Ureterolysis

Routine Ureterolysis: for all cases of the group: After entering the pelvis and before uterine vessel ligation, routine bilateral ureterolysis will be performed. The retroperitoneal space will be opened by incising the peritoneum overlying the ureter, followed by careful blunt and sharp dissection to identify each ureter and trace its course from the pelvic brim toward the uterine artery and ureteric tunnel. Surrounding tissue will be dissected only to the extent necessary to obtain clear visualization and safe lateralization of the ureter before completing the hysterectomy. Excessive skeletonization, thermal spread, and disruption of the ureteral blood supply will be avoided. The procedure will be performed using a standardized technique and documented in the operative record.

Selective Ureterolysis: for selected cases of the group: After entering the pelvis and before uterine vessel ligation, routine bilateral ureterolysis will be performed. The retroperitoneal space will be opened by incising the peritoneum overlying the ureter, followed by careful blunt and sharp dissection to identify each ureter and trace its course from the pelvic brim toward the uterine artery and ureteric tunnel. Surrounding tissue will be dissected only to the extent necessary to obtain clear visualization and safe lateralization of the ureter before completing the hysterectomy. Excessive skeletonization, thermal spread, and disruption of the ureteral blood supply will be avoided. The procedure will be performed using a standardized technique and documented in the operative record.

Study summary

To evaluate whether routine ureterolysis during Total Laparoscopic Hysterectomy for benign gynecologic conditions affects operative efficiency and perioperative safety compared with a selective ureterolysis approach.

Eligibility

Sex

FEMALE

Min age

35 Years

Max age

70 Years

Healthy volunteers

Inclusion Criteria: Women aged 35-70 years Scheduled for TLH for benign indications: Symptomatic fibroids, Abnormal uterine bleeding, Adenomyosis, Endometrial hyperplasia, Pelvic organ prolapse requiring hysterectomy, Chronic pelvic pain, Uterine size ≤16 weeks Exclusion Criteria: * Previous pelvic radiation * Known ureteric abnormalities or pathology * Severe cardiopulmonary disease precluding laparoscopy * Inability to provide informed consent * Known retroperitoneal pathology * Emergency surgery * Uterine size \> 16 weeks

Primary outcome measure(s)

Total operative duration — day 0
Total operative duration in minutes measured from skin incision to skin closure

Trial sites (1)

Facility	City	Region	Status
Kasr Alaini gynecology and obstetrics hospital	Cairo	Cairo Governorate

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07774871 on ClinicalTrials.gov ↗ ← All trials in Egypt