Efficacy of Topical Tyrosine Versus Topical 5-Fluorouracil With Fractional Erbium YAG Laser

Condition(s) studied

Investigational drug(s) / intervention(s)

Tyrosine: to evaluate and compare the therapeutic effects of topical tyrosine and topical( 5-FU) combined with fractional erbium:YAG laser in the treatment of focal vitiligo.

Study summary

Vitiligo is an autoimmune disorder affecting the skin, specifically targeting pigment-producing melanocytes, leading to noticeable regions of depigmentation characterized by white spots.

It is a widely prevalent skin disorder globally, affecting males and females almost equally, although it is reported slightly more frequently in females. In more than 60% of patients, the disease begins before the age of 30 and It has an estimated prevalence of roughly 0.2-2% across various populations, with around 0.4% in the European-derived white (EUR) population.

Eligibility

Primary outcome measure(s)

• Treatment of Focal Vitiligo — 1 year
  To measure the efficacy of the treatment by Topical Tyrosine and Topical 5-Fluorouracil With Fractional Erbium YAG Laser in repigmentation, assessed by the change in the Vitiligo Area Scoring Index (VASI ) which is determined by summing the products of the number of hand units and the percentage of depigmentation for each lesion, using predefined categories of 0%, 10%, 25%, 50%, 75%, 90%, and 100%. where as 0% is the worst and 100% is the best.

Trial sites (1)

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