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Clinical Trials in Egypt / NCT07614932
Starting soon Not applicable

Arthroscopic Lysis and Lavage With and Without Intra-articular Injection of Hyaluronic Acid in Patients With DDwoR in TMJ

NCT07614932 · tracked via the Priya Life Science Egypt tracker
Phase
Not applicable
Started
2026-05
Last updated
2026-05-29

Condition(s) studied

TMJ Disc DisorderTemporomandibular Joint Disc Displacement, Without ReductionTMD/Orofacial PainTemporomandibular DisorderTMJ Closed Lock

Investigational drug(s) / intervention(s)

Arthroscopic lysis and lavagearthroscopic lysis and lavage with intra-articular injection of hyaluronic acid

Arthroscopic lysis and lavage: Arthroscopic lysis and lavage without intra-articular hyaluronic acid injection

arthroscopic lysis and lavage with intra-articular injection of hyaluronic acid: Arthroscopic lysis and lavage followed by intra-articular injection of hyaluronic acid

Study summary

The study aims to assess the outcomes of arthroscopic lysis and lavage procedure with and without single intra-articular injection of hyaluronic acid in managing patients with anterior disc displacement without reduction.

The research question that this study will answer is:

Does arthroscopic lysis and lavage combined with hyaluronic acid provide better outcomes in terms of pain intensity and maximum mouth opening compared to arthroscopic lysis and lavage alone?

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Adults above 18 years old. 2. Diagnosis of Disc Displacement Without Reduction (DDWOR) with limited mouth : eitherunilateral or bilateral based on the DC/TMD and confirmed with MRI 3. History of unsuccessful conservative treatment such as physical therapy, occlusal splints,or medications (e.g., NSAIDs, muscle relaxants) for at least 3 months. 4. Patients must sign the informed consent, understand the study procedures and potential risks, accept to volunteer in the study and be available to attend the follow-up visits. Exclusion Criteria: 1. Degenerative Temporomandibular Joint Disorders (e.g., osteoarthritis, rheumatoid arthritis). 2. History of prior TMJ surgery (e.g., joint replacement, previous arthroscopy). 3. Severe Systemic Conditions (e.g., cardiovascular disease, autoimmune disorders, uncontrolled diabetes). 4. Active joint infection, acute inflammation, or presence of any condition that may increase the risk of complications from arthroscopic surgery or injections (e.g., local infection, uncontrolled bleeding disorders). 5. Pregnancy or Breastfeeding. 6. Patients with severe Psychological Conditions (e.g., severe depression, psychosis, myofascial pain disorder) or dental related pain will be identified at the initial assessment and referred for appropriate psychological, behavioural, or dental management prior to inclusion in the study.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Faculty of Dentistry, Cairo University Cairo Egypt

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07614932 on ClinicalTrials.gov ↗ ← All trials in Egypt