Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration

Condition(s) studied

Investigational drug(s) / intervention(s)

Autologous Demineralized Dentin Graft: Autologous demineralized dentin graft prepared from extracted non-restorable teeth will be used for filling the jumping gap around immediately placed dental implants. Tooth preparation includes removal of restorations, caries, periodontal ligament, pulp tissue, calculus, and cementum, followed by grinding and demineralization using 2% nitric acid before graft placement.

Melatonin gel: Melatonin gel will be mixed with autologous demineralized dentin graft and used for filling the jumping gap around immediately placed dental implants in the maxillary premolar region to enhance osseointegration and peri-implant bone healing.

Study summary

This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar region. Thirty patients requiring extraction and immediate implant placement will be randomly allocated into two groups. Clinical and radiographic outcomes including implant stability, peri-implant probing depth, modified bleeding index, marginal bone loss, buccal bone thickness, and bone density will be evaluated over a 9-month follow-up period.

Eligibility

Primary outcome measure(s)

• Implant Stability Quotient (ISQ) — Baseline and 6 months
  Measured using Penguin device immediately after implant placement and after 6 months.
• Jumping Distance — Immediate postoperative and 9 months after implant placement
  The horizontal bucco-implant gap (jumping distance) will be measured radiographically using CBCT at 0 mm, 2 mm, and 5 mm apical to the implant shoulder as the perpendicular distance from the implant surface to the inner buccal bone plate.
• Bone Density — Immediate postoperative and 9 months after implant placement
  Bone density around the implant will be measured radiographically using CBCT and expressed in Hounsfield units (HU) to evaluate peri-implant bone maturation and osseointegration.

Trial sites (1)

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