Root canal treatment: Root canal treatments with administration of intracanal medicaments
Study summary
The objective of this study is to investigate "clinically" the effectiveness of Oleanolic acid based intracanal medicament compared to the commonly used intracanal medicaments (Calcium hydroxide and Ledermix) on the levels of bacteria in root canals and inflammatory cytokines in the periradicular tissues of teeth with apical periodontitis.
Eligibility
Sex
ALL
Min age
20 Years
Max age
60 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. Single rooted teeth with pulp necrosis and apical periodontitis.
2. The age ranges from 20 to 60 years.
Exclusion Criteria:
1. Patient receiving antibiotic treatment within the preceding 3 months.
2. Patient reporting systemic disease.
3. Teeth that can not be isolated with rubber dam.
4. Teeth with periodontal pockets deeper than 3 mm.
Primary outcome measure(s)
Relief of signs and symptoms of apical periodontitis — 1 Week Absence of discomfort with percussion, Absence of inflammatory exudate from the root canal.
Decrease in bacterial count within the root canal. — 1 week A sample will be taken from the canal to assess the decrease in bacterial count inside the root canal by the effect of intracanal medicament.
Decrease in interleukin TNF-alpha, IL-1 Beta and PG-E2 in the periapical tissues — 1 week A sample will be taken from the periapical region to detect the effect of the intracanal medicaments in reducing inflammation and promoting healing in the periapical region.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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