Platelet rich fibrin: platelet rich fibrin is obtained by removing the middle layer from a centrifuged blood sample and is rich with platelets that plays an important role in tissue regeneration mesoporous silica nanoparticles are high surface area and excellent biocompatibility and enhance the outcome hyalurnic acid nanoparticles are high water capacity and involved in cell proliferation and adhesion and help in tissue regeneration pomegranate nanoparticles has anti-inflammatory and antibacterial effect and also help in tissue proliferation and regeneration
Study summary
the clinical trial aims to evaluate efficency of different scaffolds in cases of regeneration
Eligibility
Sex
ALL
Min age
9 Years
Max age
18 Years
Healthy volunteers
No
Inclusion Criteria:• Patients free from any systemic diseases that may interfer with the normal healing process.
* Maxillary traumatized or cariously exposed non-vital immature anterior teeth.
* Teeth don't need for post and core as a final restoration.
* Radiographic evidence of an apical opening width more than 2 mm with or without periapical radiolucency.
* Teeth without anatomical variations
Exclusion Criteria:• Immunocompromised patients
* Teeth with previous endodontic treatment.
* Teeth with internal or external resorption
* Radiographic evidence of root fracture.
* Lack of patient and parent cooperation.
* Presence of periodontal pocket depth more than 4 mm.
Primary outcome measure(s)
apical closure assessed radiographically — 12 months after treatment radiographic evaluation of apical closure as reduction or elimination of the apical opening of the root
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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