propranolol: This group Will receive propranolol intravenously at a dose of 1 mg every 6 h for 7 days, and doses will be held if heart rate less than 60 bpm, mean arterial pressure less than 65 mmHg
normal saline IV: This group Will receive 1ml of sterile 0.9% normal saline IV every 6 hours for 7 days
Study summary
The role of nonselective beta adrenergic blocker as antistress agent in severe traumatic brain injury
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients aged between 18and 65 years old
* Patients who have Severe traumatic brain injury
* Glascow outcome scale ≤ 8
Exclusion Criteria:
* Patients have pre-existing heart disease.
* If there are contraindications to β blocker.
* penetrating traumatic brain injury.
* pre-injury brain dysfunction.
* β-blocker or α2-agonist use before trauma.
Primary outcome measure(s)
Mortality — 7 days Mortality in severe traumatic brain injury with usage of β blocker
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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